摘要
目的 :探讨进展期胃癌围手术期细胞免疫功能的变化。方法 :采用间接荧光法和LDH释放法对 5 2例进展期胃癌围手术期外周血NK细胞活性、T细胞亚群进行检测。结果 :进展期胃癌患者术前外周血NK细胞活性、CD3+ 、CD4+ 细胞明显低于正常对照组 ,CD8+ 细胞却明显增高。术后 ,上述指标均可获得显著改善。结论 :进展期胃癌细胞免疫功能抑制主要是肿瘤负荷所致 ,为改善患者免疫状态 ,应力争外科手术治疗。
Objective:To study the change of perioperative cytoimmune function in AGC patients.Methods:NK activity and T lymphocyte subsets in peripheral blood of 52 AGC patients were monitored perioperatively by means of MTT and immunofluorescence technique.Results:CD3 +,CD4 + and NK activity in AGC group were lower than those in the control group,while CD8 + was remarkably higher. But after operation cytoimmune function began to restore gradually.Conclusion:Cytoimmune function of AGC patients was suppressed by the tumour load.It's necessary for AGC patients to be operated on in order to improve their cytoimmune functiom.
关键词
T淋巴细胞亚群
NK细胞
进展期胃癌
围手术期
stomach neoplasms/SU
inrtaoperative period
T lymphocyte subsets
killer cells,natural
