脾瘅宁治疗糖调节受损72例

Pidanning in Treatment Of Impaired Glucose Regulation: An Observation of 72 Cases

目的:考察脾瘅宁对糖调节受损患者血糖、胰岛β细胞功能及胰岛素抵抗的影响。方法:72例IGR患者随机分为两组,治疗组34例,对照组38例。两组患者均经健康教育后予糖尿病饮食和运动治疗。在此基础上,治疗组在生活方式干预的基础上加服中药汤剂脾瘅宁,每次饮用1袋,每天两次,于早、晚餐后30 min温服,疗程为4周。对照组予金芪降糖片,饭前半小时口服,每次7～10片,每日3次。观察体重指数、空腹及餐后2 h血糖、空腹胰岛素并计算HO-MA-β、HOMA-IR。结果:观察组和对照组患者的空腹血糖及葡萄糖耐量2 h血糖在治疗后水平均有所下降,且与治疗前相比有显著差异(P<0.05);金芪降糖片组空腹胰岛素水平较治疗前无变化,脾瘅宁组较治疗前水平有显著差异(P<0.05);脾瘅宁组与金芪降糖片组均有改善胰岛素抵抗的作用,HOMA-IR与治疗前相比均有显著差异(P<0.05);金芪降糖片组胰岛β细胞功能较治疗前无明显改善,脾瘅宁组较治疗前有明显改善,脾瘅宁组HOMA-β较治疗前有显著差异(P<0.05)。结论:脾瘅宁中药煎剂用于治疗糖调节受损,可通过改善患者胰岛素抵抗及胰岛β细胞功能,有效降低患者的空腹血糖水平、餐后2h血糖水平而改善患者的预后转归情况,该药无不良作用,疗效明显,具有临床推广意义。

Objective ： To study the effect of Pidanning on the blood glucose, beta cell function and insulin resistance of patients with impaired glucose regulation. Methods：72 patients with IGR were randomly divided into two groups, 34 cases in treatment group ,38 cases in the control group. Two groups＇patients after health education were given diet and exercise therapy for diabetes. On this foundation, the treatment group added the lifestyle interventions based on Herbal Drug Decoction Pidanning, 1 bag for each time, twice a day, 30 rain after breakfast and dinner, a course of 4 weeks. The control group received Jinqi Jiangtang Tablet orally, half an hour before meals ,7 -10 tablets for each time, 3 times a day. Observations of BMI, fasting and postprandial plasma glu- cose, fasting insulin and 2h calculation of HOMA -β, HOMA - IR were carried on. Results ： In the treatment group and the control group ,fasting blood glucose and glucose tolerance of blood glucose in the treatment of 2 h after water average decreased compared with those before treatment, and there were significant differences （P 〈 0. 05 ）. The fasting insulin levels in Jinqi Jiangtang Tablet group had no change, and that in Pidanning group had significant difference （ P 〈 0. 05 ）. Pidanning group and Jinqi Jiangtang Tab- let group could improve insulin resistance. HOMA - IR in Pidanning group had a significant difference compared with those before treatment （P 〈0. 05）. Jinqi Jiangtang Tablet groupg pancreatic islet beta cell function showed no improvement after treatment. HOMA - β in Pidanning group had improved significantly than that before treatment （ P 〈 0. 05 ）. Conclusion ： Traditional Chinese medicine decoction for treating spleen settling on impaired glucose regulation, can improve insulin resistance and beta cell func- tion, effectively reduce the fasting glucose level, 2 h postprandial blood glucose levels and improve the prognosis of the patients prognosis. The drug has no adverse effects, but has significant efficacy.