滋水通脉饮治疗2型糖尿病颈动脉硬化患者30例

Clinical Observation of Zishui Tongmai Decoction in Treatment 30 Cases of Type 2 Diabetes Patients with Carotid Atherosclerosis

目的:观察滋水通脉饮治疗2型糖尿病颈动脉硬化患者的临床疗效,并探讨其可能作用机理。方法:60例2型糖尿病颈动脉硬化患者随机分为治疗组和对照组各30例,对照组服用辛伐他汀片40mg治疗,治疗组在此基础上加用滋水通脉饮治疗,疗程8周。结果:治疗组临床疗效明显优于对照组(P<0.01);且降低血清可溶性细胞间黏附因子-1(sICAM-1)、糖化血红蛋白(HbA1c)水平、减少斑块总积分较对照组更显著(P<0.05)。结论:滋水通脉饮可能通过降低sICAM-1水平来改善2型糖尿病患者颈动脉硬化程度。

Objective：To observe the clinical curative effect of Zishui Tongmai Decoction in the treatment of type 2 diabetes patients with carotid atherosclerosis, and discuss the possible mechanism of action. Methods ：60 cases of type 2 diabetes patients with carotid atherosclerosis were randomly divided into 2 groups. 30 patients in control group received Simvastatin tablets. 30 pa- tients in treatment group were treated by Zishui Tongmai Decoction on the basis. The period of treatment was 8 weeks. Results： Clinical curative effect of the treatment group was better than that of the control group （ P 〈 0.01 ）. The treatment group reduced levels of slCAM - 1 and HbA1 c. The reduce degree of total integral of plaques was more obvious than that of the control group （P 〈 0. 05）. Conclusion ： Zishui Tongmai Decoction may improve the level of carotid atherosclerosis of type 2 diabetes patients by lowering sICAM - 1.