养心安神汤联合认知-行为疗法治疗原发性失眠的临床研究

Clinical Research on Yangxin Decoction Combined Nerves Cognitive-Behavioral Therapy in Treatment of Insomnia

目的:观察养心安神汤联合认知-行为疗法治疗原发性失眠的短期疗效。方法:180例原发性失眠患者随机分成3组:认知-行为治疗组、养心安神汤治疗组和养心安神汤联合认知行为治疗组(联合治疗组)。观察并比较3组患者总体临床疗效、治疗前后匹兹堡睡眠质量指数(PSQI)积分变化情况。结果:治疗1周后认知-行为治疗组、养心安神汤治疗组和联合治疗组总有效率分别为70.00%、81.66%、91.66%,3组比较有显著统计学意义(P<0.01);治疗4周后认知-行为治疗组、养心安神汤治疗组和联合治疗组总有效率分别为88.33%、91.66%、96.66%,3组比较有显著统计学意义(P<0.01)。治疗1周后养心安神汤治疗组以及联合治疗组较认知-行为治疗组PSQI有显著统计学意义(P<0.01);养心安神汤治疗组和联合治疗组PSQI相比无统计学意义(P>0.05);治疗4周后联合治疗组较认知-行为治疗组以及养心安神汤治疗组PSQI有显著统计学意义(P<0.01),养心安神汤治疗组与认知-行为治疗组PSQI差异无统计学意义(P>0.05)。认知-行为治疗组、养心安神汤治疗组和联合治疗组不同时间点PSQI自身对照比较均有显著统计学意义(P<0.01)。结论:养心安神汤联合认知-行为疗法治疗原发性失眠短期疗效满意,无不良事件发生。

Objective ： To observe the short - term curative effect of Yangxin Decoction combined nerves cognitive - behavioral therapy in the treatment of insomnia. Methods： 180 cases of primary insomnia patients were randomly divided into three groups： cognitive - behavioral therapy group, Yangxin Decoction and the combined treatment group. The overall clinical curative effect as well as Pittsburgh sleep quality index （PSQI） integral change was observed and compared before and after treatment. Results ： One week after treatment, the total effectiveness of cognitive - behavioral therapy group, Yangxin Decoction treatment group and com- bined treatment group was 70. 00% ,81.66% and 91.66% respectively. The differences had statistically significant meaning（P 〈 0. 01 ）. Four weeks after treatment, the total effectiveness of cognitive-behavioral therapy group, Yangxin Decoction treatment group and combined treatment group was 88.33% ,91.66% and 96.66% respectively. There was a significant difference（ P 〈 0. 01 ）. One week after treatment, PSQI value in Yangxin Decoction treatment group and the combined group was decreased obviously （ P 〈 0. 01 ）. There was statistical significance （P 〉 0. 05 ）. Four weeksafter treatment, PSQI in combined group and Yangxin De- coction treatment group was declined obviously （P 〈 0. 01 ）. The diffelence was not statistically significant （P 〉 0. 05 ）. PSQI at different time points in cognitive - behavioral therapy group, Yangxin Decoction trSatment group and combined group had signifi- cant difference（P 〈 O. 01 ）. Conclusion：Yangxin Decoction combined nerves cognitive ^- behavioral therapy treatment has satisfac- tory effect of insomnia without adverse events.