1AKDIM F,STROES E S,SUBRANDS E J,etal. Efficacy andsafety of mipomersen,an antisense inhibitor of apolipoproteinB, in hypercholesterolemic subjects receiving stable statintherapy[J].J Am Coll Cardiol,2010 15(55) :1611 -1618.
2VISSER M E, AKDIM F,TRIBBLE D L,et al. Effect of apo-lipoprotein-B synthesis inhibition on liver triglyceride contentin patients with familial hypercholesterolemia [ J]. J LipidRes,2010 55:1057 -1062.
3KROTZ A H,GORMAN D,MATARUSE P,et al. Phosphoro-thioate oligonucleotides with low phosphate diester content :greater than 99. 9% sulfurization efficiency with44 Aged" solu-tions of phenylacetyl disulfide(PADS) [ J]. Org Process ResDev,2004,8(6) ;852 -858.
