喹赛多的合成工艺研究

The Synthesis Technologic Study of Cyadox

以苯并呋咱-N-氧化物和丙酮醛缩二甲醇为起始原料,N,N-二甲基甲酰胺为溶剂,吡咯烷为催化剂,经过Beirut反应得到喹噁啉-1,4-二氧-2-甲醛缩二甲醇,喹噁啉-1,4-二氧-2-甲醛缩二甲醇在以甲醇为溶剂、浓盐酸为催化剂的条件下与氰乙酰肼反应生成喹赛多。终产物喹赛多经核磁共振氢谱、核磁共振碳谱、质谱、红外光谱进行确证。总收率为55.8%。

2- formylquinoxaline -1, 4 -dioxide dimethylacetal was obtained by benzofuroxan -N -oxide and pyruvaldehyde dimethylaeetal which were dissolved in N, N - dimethyl formamide and pyrrolidine was used as catalyzer. 2 -formylquinoxaline- 1, 4 -dioxide dimethylacetal was dissolved in methanol and concentrated hydrochloric acid, then reacted with cyanoacetylhydrazine to obtain cyadox. Cyadox was identified by 1H - NMR, ~3C -NMR, MS, and IR. The total yield was 55.8%.