磺脲类药物继发性失效的Ⅱ型糖尿病加用拜糖平的疗效观察

Efficacy of Acarbose in Combination with Sulfonylurea for Treatment of Type Ⅱ Diabetes Mellitus with Secondary Failure to Sulfonylurea Medication

目的 观察Ⅱ型糖尿病人对磺脲类药物继发性失效加用拜糖平的疗效。方法 将 46例磺脲类药物继发性失效的Ⅱ型糖糖尿病人在治疗上加用拜糖平 ,治疗 3个月 ,观察疗效。结果 经拜糖平治疗后 ,患者的空腹血糖进一步下降 (P <0 .0 5 ) ,餐后第 1、第 2小时的血糖明显下降 (P <0 .0 1)糖化血红蛋白明显下降 (P <0 .0 1) ,有效率为 47 7%。结论 加用拜糖平可作为磺脲类药物继发性失效后的有效治疗方法之一 ,对延缓和减少糖尿病慢性并发症具有重要临床意义。

Objective To study the therapeutic efficacy of acarbose in addition to sulfonylurea drugs for treatment of type Ⅱ Diabetes Mellitus (NIDDM) with secondary failure to sulfonylurea medication.Method 40 NIDDM patients with secondary failure to sulfonylurea medication were treated by addition of acarbose for three months and the therapeutic effect was observed.Results After three months of treatment,patients's fasting blood sugar and the first and second hour's postprandial blood sugar levels were significantly decreased with effective rate 47.7%.Conclusion Addition of acarbose is one of the choices in treatment of NIDDM with secondary failure to sulfonylurea medications.