期刊文献+

血清胱抑素C检测在糖尿病肾病患者肾功能评价中的诊断价值 被引量:13

下载PDF
导出
摘要 目的探讨血清胱抑素C检测在糖尿病肾病患者肾功能评价中的诊断价值。方法选择我院2012年4月—2012年12月内科收治的糖尿病肾病患者80例,经同位素法测定确定,以同位素测定结果为标准,抽取患者空腹血液离心分离血清后分别进行血清胱抑素C检测、血尿素氮检测、血肌酐检测,对比三种检测方法阳性率。结果以同位素检测结果为标准,血清胱抑素C检测阳性率为95.00%,血尿素氮检测阳性率为68.75%,血肌酐检测阳性率为62.50%,血清胱抑素C检测阳性率分别与血尿素氮检测、血肌酐检测阳性率比较,差异有统计学意义(P<0.05);而血尿素氮与血肌酐检测阳性率比较,差异无统计学意义(P>0.05)。结论血清胱抑素C检测可以及早反应糖尿病肾病患者肾功能损伤,且可以准确反应肾功能受损程度,在糖尿病肾病的早期诊断中具有重要意义。
作者 戴惠清
出处 《临床合理用药杂志》 2013年第21期86-87,共2页 Chinese Journal of Clinical Rational Drug Use
  • 相关文献

参考文献3

二级参考文献26

  • 1俸家富,罗军,李少林.胱抑素C——肾小球滤过率肌酐替代标记物[J].国外医学(临床生物化学与检验学分册),2005,26(3):168-172. 被引量:112
  • 2彭炎强,史伟,叶智明,梁馨苓,何朝生,章斌,王文健,梁永正.检测血清胱抑素C诊断急性肾衰竭的研究[J].新医学,2005,36(10):570-572. 被引量:23
  • 3董梅,孟祥红,佟爱华,李艳艳,吴纯.血清胱抑素C在评价糖尿病患者早期肾损伤中的价值[J].中国实验诊断学,2006,10(6):642-643. 被引量:32
  • 4GRUBB A,SIMONSEN O,STURFELT G,et al. Serum concentration of cystatin C,factor D and β2 - micmglobulin as a measure of glomemlar fihration rate [ J ]. Acta Med Scmld, 1985,218:499 - 503.
  • 5FINNEY A H,NEWMAN D J,GRUBER W,et al. Initial evaluation of cystatin C measurement by particle - enhancexl irmnunonephelometry on the Behring nephlometersystems ( BNA, BNII) [ J ]. Clin Chem, 1997,43 : 1016- 1022.
  • 6CRAWFORD B F C, FREEMAN M J, SCI-ILNKA J A, et al A polymor - phism in cystatin C gene is novel risk factor late - onset Alzheimer's desease[J]. Neurology,2000,55(2) :763 - 768.
  • 7JANOW SKI R,KOZAK M,JANKOW SKA E,et al. Human Cystatin C, a protein with amy loidogenic properties,dimerizes through 3D domains wapping[ J]. Net Struct Biol ,2001,8 :316 - 320.
  • 8NEWAN D D J ,THAKKAR H ,I DWARDS RQ,et al. Serum Cystatin C measured inununoasay. A more sensitive marker of changes in GFR than serum creatinine[ J ]. Kidney Int,1995,47(1) :312 - 318.
  • 9GOKKUS C A,OZDEN T H,GUL H,et al Relationship between plasma Cystatin C and crealinine in chronic renal disease and Tx - transplant patients[J].Clon Biochem,2004,37(2) :94 - 97.
  • 10GALTEAU M M, GUYON M, GUEGUEN R, et al. Determination of serum cystatin C:biological variation and reference values [ J ]. J Clin Chen Lab Med ,2001,39(9) :850 - 857.

共引文献28

同被引文献90

  • 1Theodosios D Filippatos,Moses S Elisaf.Effects of glucagon-like peptide-1 receptor agonists on renal function[J].World Journal of Diabetes,2013,4(5):190-201. 被引量:9
  • 2俸家富,罗军,李少林.胱抑素C——肾小球滤过率肌酐替代标记物[J].国外医学(临床生物化学与检验学分册),2005,26(3):168-172. 被引量:112
  • 3程苏琴,朱美财.尿微量白蛋白在糖尿病肾损伤早期诊断中的价值[J].中华检验医学杂志,2005,28(7):740-741. 被引量:203
  • 4叶任高,陆在英.内科学.第6版.北京:人民卫生出版社,2005:95-96.
  • 5Borges RI, Himta AH, Quinto BM, et al. Is cystatin C a useful marker intbe detection of diabetic kidney discase [ J ]. Nephron Clin Praet, 2009,114(2) :127.
  • 6Perkins BA, Nelson RG, Ostrander BE, et al. Detection of renal function decline in patients with diabetes and normal or elevated GFR by serial measurements of serum cystatin C concentration : re- suits of a 4-year follow-up study [ J ]. J Am Soc Nephrol, 2005, 16(5) :1404-1412.
  • 7Swiatio E, King J, Nabors CS, et al. Pneumocoeeal surfaceprotein A is expressed in vivo, and antibodies to Psp A are effectivefor therapy in a murine model of pnemococcal sepsis [J ]. InfectIm- mum, 2003,71 (12) :7149.
  • 8Hating N, Mahr HS, Mundle M, et al. Early detection of renal- damage caused by fumaric acid estertherapy by determination ofuri- nary 132-microglobulin [ J ]. Dr J Dermatol, 2011,164 ( 3 ) : 648.
  • 9王译晨.血清胱抑素c测定对糖尿病肾病早期诊断的临床意义[A]//吉林大学[c].2011.
  • 10王冰,孙焱,张焱,等.西格列汀对2型糖尿病尿微量白蛋白的影响及机制[J].中华临床医师杂志:电子版,2013,7(8):3607-3608.

引证文献13

二级引证文献68

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部