摘要
目的系统评价根除幽门螺杆菌(HP)治疗帕金森病的有效性和安全性。方法制定严格纳入和排除标准,计算机检索Cochrane图书馆临床对照试验数据库(2012年)、MEDLINE或PubMed(1978~2012年)、Embase(1978~2012年)、OVID数据库(1978~2012年)、中国生物医学文献数据库(CBMDisc)(1978~2012年)、维普中文期刊数据库(1989~2012年)、中国期刊全文数据库(1979~2012年)、万方学位论文数据库(1978~2012年)。并手工检索相关会议论文集及查阅检索到的所有文献的参考文献,全面收集关于根除幽门螺杆菌治疗帕金森病的随机对照试验。按国际Cochrane协作网推荐的方法进行系统评价。结果共纳入3个试验106例患者。1篇纳入21例患者的研究显示,根除Hp治疗可改善PD患者平均步伐宽度、手臂活动情况、姿势步态;1篇纳入36例患者的研究显示,左旋多巴联合根除Hp治疗可提高左旋多巴吸收率,改善症状波动PD患者的PD评估量表(UPDRS)、开期时间变化;另1篇纳入49例患者的研究结果显示,根除Hp治疗可改善PD患者症状。且3篇研究均无根除Hp治疗相关不良反应及并发症发生。结论有限的证据表明:根除Hp治疗可提高PD患者左旋多巴吸收率,改善PD症状,安全性好。但仍需大量循证医学证据的进一步积累,从而指导临床实践。
Objective To system review the effectiveness and safety of eradication helicohacter pylori(HP) in treat ment of parkinson's disease. Methods Formulate strict inclusion and exclusion criteria. Computer retrieve controlled clinical trial database(2012) of Cochrane library, Medline, Pubmed( 1978 - 2012), Embase ( 1978 - 2012), OVID Database ( 1978 - 2012), Chinese Biological Medicine database (CBMDisc) ( 1978 - 2012), rip database of chinese science and technology peri odicals( 1989 -2012) ,cnki database ( 1979 to 2012) ,Wanfang dissertation database( 1978 -2012). Manual retrieval relevant conference proceedings, cousuit the reference documentation of retrieved literature, comprehensive collect the randomized con trolled trial of helicobacter pylori in Parkiuson' s disease, evaluated adopted the method recommended by International Corehrane Collaboration. Results Systematic review included 3 trials, 106 cases of Parkiuson's disease. One literature(21 ca- ses) show that Hp erdication therapy can improve the average pace width PD patients,arm activities,gait and posture. One lit erature (36cases) show that levedopa combined with the eradication of HP can improve the absorbed dose, updrs of PD patients with symptoms fluctuations and open time. One literature (49cases) show that eradicate of HP cam improve the symptoms of PD. No eradication of HP-related adverse reactions and complications in 3 literature. Conclusion Limited evidence suggests that eradication HP can improve the levodopa absorption of patients with HP,improve symptoms,and the security is good. Guide the clinical practice need large quantity evidence of evidence-based medicine.
出处
《临床合理用药杂志》
2013年第22期7-9,共3页
Chinese Journal of Clinical Rational Drug Use
关键词
幽门螺杆菌
帕金森病
系统评价
Helicobacter pylori
Parkinson's disease
Systematic review