空腹血糖受损人群自然转归及其影响因素的观察

Natural outcome and its correlated factors in patients with impaired fasting glucose

目的探讨开滦研究中IFG人群的自然转归及其影响因素。方法采用前瞻性队列研究,对FPG 6.1～7.0mmol/L且无糖尿病史的IFG人群,随访2年。结果 (1)最终共纳入IFG者5562例,随访2年后2985例(53.7%)血糖降至正常,1305例(23.5%)仍为IFG,1272例(22.9%)诊断为糖尿病;(2)分别以血糖转为正常或进展为糖尿病为因变量,以各危险因素作为自变量行多因素Logistic回归分析,结果显示年龄、BMI、WHR、SBP、LDL-C水平是进展为糖尿病的危险因素。结论 IFG人群约22.9%进展为糖尿病。年龄、BMI、WHR、LDL-C水平是进展为糖尿病的危险因素。

Objective To study the natural outcome in patients with impaired fasting glucose （IFG） and analyse its influencial factors. Methods In this prospective cohon study, participants with FPG from 6.1 to 7.0 mmol/L and without history of diabetes were screened and followed up for 2 years. Results There were 5562 people with IFG recruitted in the study. During the 2-year follow-up, 1272 （22.9%） people developed diabetes, 2985 （53.7%） people regressed to normoglycaemia, and 1305 （23.5%） people with IFG remained unchanged. Taking the blood glucose changing to normal or progressing to diabetes as the independent variables and the risk factors as dependent variables, the multiple factors logistic regression analysis showed that the age, BMI, WHR, SBP, and LDL-C were the risk factors for developing diabetes. Conclusion Approximately 22.9% people with IFG develop diabetes. The age, BMI, WHR, and LDL-C are the independent factors of developing into diabetes.