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奥美沙坦酯及其关键中间体的合成方法 被引量：4

Summary of synthesis methods of olmesartan medoxomil and key intermediates
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摘要 奥美沙坦酯,一种血管紧张素Ⅱ1型受体(AT1)拮抗剂,用于高血压病的治疗。将该化合物的合成路线及其关键中间体——2-丙基-4-(1-羟基-1-甲基乙基)-1H-咪唑-5-羧酸乙酯和2-腈基-4'-甲基联苯(CMBP)的各种合成方法作一综合性论述。 Olmesartan medoxomil, an angiotensin Ⅱ 1 receptor （AT1） antagonist,is widely used for the treatment of hyper-tension and related diseases. This review summarized the syn- thesis methods of olmesartan medoxomil and the key interme-diates ethyl 4-（2-hydroxypropan-2-yl） -2-propyl-1H-imidaz-ole-5-carboxylate and 2-cyano-4＇-methyl-biphenyl （CMBP） thereof. Furthermore, each synthetic route was evaluated and compared with others.
作者 韩薇薇 吴金龙
机构地区 浙江大学化学系不对称催化及合成实验室
出处 《化学试剂》 CAS CSCD 北大核心 2013年第8期711-716,共6页 Chemical Reagents
关键词 奥美沙坦酯 合成 2-丙基-4-(1-羟基-1-甲基乙基)-1H-咪唑-5-羧酸乙酯 2-腈基-4'-甲基联苯 olmesartan medoxomil synthesis intermediate ethyl 4-（ 2 -hydroxypropan-2-yl）-2-propyl-1 H -imidazole-5-car-boxylate 2-cyano-4＇-methyl-biphenyl
分类号 O626 [理学—有机化学]
  • 相关文献

参考文献22

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二级参考文献33

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共引文献22

同被引文献19

  • 1虞心红,汤建,温新民,毛庆华,沈永嘉.抗高血压新药奥美沙坦的合成[J].华东理工大学学报（自然科学版）,2005,31(2):189-192. 被引量：9
  • 2翁水旺.反相高效液相色谱法测定奥美沙坦酯的有关物质[J].药物分析杂志,2006,26(5):686-688. 被引量：6
  • 3吴泰志,刘晓华,张福利,谢美华.抗高血压药奥美沙坦酯合成新路线和相关杂质的研究[J].药学学报,2006,41(6):537-543. 被引量：14
  • 4何其林,耿玉先.一种奥美沙坦酯的制备方法:中国,1680335[P].2005-10-12.
  • 5YANAGISAWA H, AMEMIYA Y, KANAZAKI T, et al. Nonpeptide angiotensin I[ receptor antagonists: synthesis, biological activities, and structure-activity relationships of imidazole-5-carboxylic acids bearing alkyl, alkenyl, and hydroxyalkyl substituents at the 4-position and their related compounds [J]. J Med Chem, 1996, 39(1): 323-338.
  • 6JEONG-SOO C, MOHAMMED I E-G, CHANG-HYUN O, et 1. Design, synthesis, bioconversion, and pharmacokinetics evaluation of new ester prodrugs of olmesartan [J]. Eur J Med Chem, 2011, 46(9): 3564-3569.
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  • 8VEVERKA M, PUTALA M, BRATH H, et al. Process for the preparation of sartan derivatives and intermediates useful in such process [P]. US: 7868180B2, 2011-01-11.
  • 9ALDO S, RENATO C. Process for the preparation of 4-bromomethyl diphenyl compounds: US, 6111114A [P]. 2000-08-29.
  • 10潘红娟,吴泰志,张福利,俞雄.奥美沙坦酯及其相关物质的分离与测定[J].药物分析杂志,2008,28(11):1883-1887. 被引量：11

引证文献4

二级引证文献5

化学试剂
2013年 第8期

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