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对硝基苯氧丙酮吡唑衍生物的合成

Synthesis of novel p-nitrophenoxy acetone 1H-pyrazole derivatives
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摘要 以对硝基苯酚、苯乙酮衍生物、草酸二甲酯为原料,经过取代、环化等反应,合成了5种新的对硝基苯氧丙酮吡唑衍生物,本合成操作简单、产品易精制,所得新化合物均经1HNMR、13CNMR和ESI-MS进行了结构表征。 A series of 4-nitrophenoxy acetone containing ^1H-pyrazole derivatives were synthesized from 4-nitrophenol, ace-topenone derivatives and dimethyl oxalate via substitution and cyclization. Synthetic method has the simplicity of operator, and easy refinning. The structures were confirmed by ^1 HNMR,^13 CNMR and ESI-MS.
作者 孟启 王守文 姜艳 周长青 孙小强
机构地区 常州大学石油化工学院
出处 《化学试剂》 CAS CSCD 北大核心 2013年第8期759-762,共4页 Chemical Reagents
关键词 对硝基苯酚 1-氯丙酮 对硝基苯氧丙酮吡唑衍生物 合成 4-nitrophenol 1 -chloropropan-2-one 4-nitrophe-noxy acetone containing ^1H-pyrazole derivatives synthesis
分类号 O625.4 [理学—有机化学]
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  • 1BOVENS S, ELFRINGHOFF A S, KAPTUR M. 1-(5-Car- boxyindol-l-yl) propan-2-one inhibitors of human cytosol- ic phospholipase A2a:effect of substituents in position 3 of the indole scaffold on inhibitory potency,metabolic sta- bility,solubility, and bioavailability [ J ]. J. Med. Chem. , 2010,53(23) :8 298-8 308.
  • 2LI Yan, ZHANG Hong-quan, YANG Xiang-ping, et al. Stereoselective synthesis and antifungal activities of (E)- a-(methoxyimino)-benzeneacetates derivatives containing 1,3,5-substituted pyrazole ring [ J ]. Agric. Food Chem. , 2006,54(10) :3 636-3 640.
  • 3KEES K L,STEINER K E,MCCALEB M L. New potent antihyperglycemic agents in db/db mice: synthesis and structure-activity relationship studies of (4-substituted benzyl) (trifluoromethyl) pyrazole and -pyrazolones [ J ]. J. Med. Chem. ,1996,39(20) :3 920-3 928.
  • 4SELWOODL D L,BRUMMELL D G,HOBBS A J,et al. Synthesis and biological evaluation of novel pyrazoles and indazoles as activators of the nitric oxide receptor, soluble guanylate cyclase[ J]. J. Med. Chem. ,2001,44 ( 1 ) :78.
  • 5VINCENT F, NGUYEN M T, EMERLING D E, et al. Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH) : identification of phenme- dipham and amperozide as FAAH inhibitors[ J ] Bioorg. Med. Chem. Lett. ,2009,19(20) :6 793-6 796.
  • 6ORTAR G, MORIELLO A S, CASCIO M G, et al. New tetrazole-based selective anandamide uptake inhibitors [J]. Bioorg. Med. Chem. Lett. , 2008, 18 (9) : 2 820- 2 824.
  • 7ANDRZEJAK V, MUCCIOLI G G, BODY-MALAPEL, et al. New FAAH inhibitors based on 3-carboxamido-5-aryl-isoxazole scaffold that protect against experimental colitis [J]. Bioorg. Med. Chem. Lett. ,2011,19 (12) : 3 777- 3 786.
  • 8JOHNSON D S,AHN K,KESEN S,et a]. Benzothiophene piperazine and piperidine urea inhibitors of fatty acid am- ide hydrolase (FAAH) [ J ]. Bioorg. Med. Chem. Lett. , 2009,19(10) :2 865-2 869.
  • 9KIMBALL F S,ROMERO F A,EZZILI C ,et al. Optimiza- tion of r-ketooxazole inhibitors of fatty acid amide hydro- lase[ J]. J. Med. Chem. ,2008,51(4) :937-947.
  • 10LONG J Z, JIN Xiu, ADIBEKIAN A, et al. Characteriza- tion of tunable piperidine and piperazine carbamates as inhibitors of endocannabinoid hydrolases [ J ]. J. Med. Chem. ,2010,53(4) :1 830-1 842.

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化学试剂
2013年 第8期

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