ITP患者骨髓及血液检测指标与疗效关系的探讨

STUDY ON THE VALUES OF EXAMINED INDEXES OF PERIPHERAL BLOOD AND BONE MARROW TO PREDICTION OF THERAPEUTIC EFFECTIVENESS IN PATIENTS WITH ITP

目的 :为观察血小板表面相关抗体G(PaIgG)、外周血血小板计数 (BPC)、平均血小板容积 (MPV)、骨髓巨核细胞计数 (MK)与产板型巨核细胞比例 (PPMK)对特发性血小板减少性紫癜 (idiopathicthrombocytopenicpurpura,ITP)患者疗效的预计价值。 方法 :采用Coulter全自动血球分析仪及双抗体夹心ELISA法等 ,对 73例ITP患者治疗前和治疗后的BPC、MPV、MK、PPMK和PaIgG水平进行测定。 结果 :ITP组BPC、PPMK显著低于对照组 (P <0 .0 1 )。对照组BPC与MPV呈负相关 (P <0 .0 1 )。治疗有效病例达到有效时间与BPC、治疗前MPV、MK及PaIgG水平的相关性不明显 (P >0 .0 5) ,而与治疗前PPMK、治疗后MPV呈明显负相关 (P <0 .0 5)。结论 :治疗前骨髓PPMK及治疗后MPV与ITP的疗效及达效时间有关 。

Objective:To investigate the values of peripheral blood BPC,MPV and PaIgG,bone marrow MK count and platelet-producing megakaryocyte(PPMK) rate to the prediction of therapeutic effectiveness in patients with ITP.Methods:73 Cases of ITP were included in this study.Coulter automatic blood cell analyzer was employed to measure the levels of BPC and MPV before and after treatments.PaIgG levels were tested by Sandwich ELISA with double antibodies.Results:BPC level and PPMK rate were lower in ITP group than those in normal control group( P<0.01 ).BPC was negatively correlated to MPV in normal control group( P<0.01 ).In the cases which demonstrated responses to steroid,the response time had no significant correlations to BPC,MPV of pre-treatment,MK count and PaIgG,while had negative correlations to MPV of pro-treatment and PPMK rate of pre-treatment.Conclusion:PPMK rate of pre-treatment and MPV of pro-treatment were related to the response time and therapeutic effectiveness of steroid.They would be considered as reference indexes for the prediction of therapeutic effectiveness in ITP patients.