摘要
本文概述了制药工业中绿色化学的起源和发展,展示了绿色制药工艺的研究前沿和课题,介绍了常用的绿色技术、技巧和手段,分析了塞来昔布、西他列汀、普瑞巴林、沙格列汀、阿瑞匹坦、埃索美拉唑、多奈哌齐等药物的合成工艺改进。
This review outlined the origin and the development of green process chemistry in modern pharmaceutical industry, list the key areas of green chemistry research, introduced the green techniques, skills and approaches with cases studies of several pharmaceutical products including celecoxib, sitagliptin, pregabalin, saxagliptin, aprepitant, esomeprazole and donepezil.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2013年第8期814-827,共14页
Chinese Journal of Pharmaceuticals
关键词
绿色化学
制药工艺
催化过程
药物合成
green chemistry
pharmaceutical process
catalytic process
drug synthesis
