摘要
透明质酸具有无毒、免疫原性低、可生物降解等优点,同时在体内有多种受体,如CD44受体,可通过受体-配体机制实现靶向药物递送的目的。本文综述了各种基于透明质酸的纳米给药系统(包括药物偶联物、纳米凝胶、纳米胶束和纳米粒)的形成、物理化学特点、生物学性质及其应用,展望了其发展趋势和应用前景。
Hyaluronic acid （HA） possesses lots of advantages such as non-toxicity, low immunogenicity and biodegradability. The active targeting effect can be achieved through the interaction between HA and its receptors, especially CD 44. The purpose of this paper is to review the formulations, physicochemical and biological properties of HA-based targeted nano-drug delivery systems, such as HA-drug conjugates, nanogels, nanomicelles and nanoparticles. Trends and prospects of developments and applications of HA are introduced.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2013年第8期828-835,共8页
Chinese Journal of Pharmaceuticals
关键词
透明质酸
CD44
纳米给药系统
靶向
综述
hyaluronic acid
CD 44
nano-drug delivery system
targeting
review
