肝动脉化疗栓塞加门静脉灌输CD_3AK细胞治疗转移性肝癌的研究

Study of Combine Effect of Hepatic Arterial Chemoembolization and Portal Venous Infusion with CD_3AK cells on Patient with Metastatic Hepatic Carcinoma

目的 :观察肝动脉化疗栓塞 +门静脉插管化疗、灌输 CD3AK细胞治疗转移性肝癌的临床疗效及对机体免疫功能的影响。方法 :将 2 5例大肠癌肝转移患者随机分为 A,B两组 ,A组行肝动脉化疗栓塞 +门静脉插管化疗、灌输CD3AK细胞治疗 ,B组行肝动脉化疗栓塞 +门静脉插管化疗治疗。结果 :A组患者的细胞免疫指标在术后迅速恢复且维持在高水平状态 ,避免了机体由于手术打击而导致术后免疫力普遍降低的现象。而 B组术后细胞免疫功能较术前明显降低 ( P<0 .0 5 ) ,且恢复缓慢。A、B两组术后同期各指标相比较有显著性差异 ( P<0 .0 5 )。C组外周血单个核细胞的分布及体液免疫功能指标在术前、术后相比较无明显差异 ( P>0 .0 5 ) ,但均比 A、B组高。A组临床有效率为 80 % ,B组为 6 0 %。结论 :肝动脉化疗栓塞 +门静脉插管化疗、灌输 CD3AK细胞治疗转移性肝癌能提高临床疗效 ,提高肿瘤的 期切除率及迅速恢复。

Objective:To observe the clinical therapeutic value and effect on hostal immunol functional change for patient with secondary hepatic venous infusion with CD 3AK cells treatment.Methods:25 cases of patient with metastatic hepatic carcinoma of primary colon origin are divided randomly into group A and group B.group A,employed the combined hepatic arterial chemoembolization and portal venous infusion with CD 3AK cells procedure,while group B used the combined hepatic arterial chemoembolization only.Results:In group A,avoiding the general low immunity leave as a result of the cellular immunol index restore swifty and maintain at relatively high level postoperatively,while in group B,the cellular immunol function is obviously low and the restoration is slow.Both group A and group B index show apparent difference in same period of time(P<0.05).Effectiveness for group A is 80% while 60% for group B.Conclusion:Combined hepatic arterial chemombolization and portal venous infusion carcinoma with CD 3AK cells procedure has marked clinical therapeutic value and swift restoration.It is also effective to enhance hostal immune function.