小剂量甘露醇、苯巴比妥、脑活素联合治疗新生儿缺氧缺血性脑病临床观察

The Clinical Observation of Effects of Phenobabital Combined with Low Dose of Mannitol and Cerebrolysin in Newborns with Hypoxiaischemic Encephalopathy

目的 :探讨静脉滴注苯巴比妥、甘露醇及脑活素联合防治新生儿缺氧缺血性脑病 ( HIE)的疗效。方法 :对 30例重度窒息新生儿生后 6 h内即开始应用苯巴比妥预防缺氧后脑损伤 ,如出现 HIE症状再予小剂量甘露醇及脑活素治疗。结果 :观察组在减少 HIE的发生率、减轻脑损伤的严重程度、提高治愈率、降低病死率等临床指标与对照组有显著性差异 ( P<0 .0 5或 <0 .0 1)。结论 :应用苯巴比妥、小剂量甘露醇、脑活素联合防治新生儿 HIE疗效肯定、副作用小 。

Objective:To investigate the effects of i.v.infussion of phenobabital combined with low dose of mannitol and cerebrolysin in treatment and prevention of hypoxiaischenmic encephalopathy (HIE) in newborns. Methods: Thirty newborn babies with sever apnea were given phenobabital within 6 hours after birth to prevent hypoxia mental injury. Low dose of mannitol and cerebrolysin were applied as soon as the symptoms of HIE appeared. Results:The difference between the group treated and the control was highly significant (P<0.05 or <0.01) in incidence rate, severity, cure rate, death rate of HIE. Conclusions:The effects of phenobabital combined with low dose of mannitol and cerebrolysin for preventing and treating hypoxia ischemic encephalopathy (HIE) in newborns have been confirmed,and the side effects is few and slight, therefore it can be introduced widely for clinic use.