信法丁预防性治疗脑血管意外昏迷患者应激性溃疡的疗效探讨

Observation on famotidine in the prevention of stress ulcer in comatous patients with cerebral apoplexy

目的:探讨信法丁防治脑血管意外昏迷患者应激性溃疡的疗效。方法:在按原发病常规治疗的基础上用信法丁对104例脑血管意外昏迷患者进行预防性治疗,同期与127例仅按原发病常规治疗的患者对照,分析应激性溃疡的发生率及病死率。结果:治疗组应激性溃疡发生率为22.11％,对照组为53.54％(P<0.01)。治疗组患者病死率为10.58％,对照组为48.03％(P<0.01)。结论:信法丁的干预可减少脑血管意外昏迷者并发应激性溃疡发生率,降低病死率。

Objective:To investigate the efficacy of famotidine in the prevention of stress ulcer in comatous patients with cerebrovascular accidents. Methods: Comatous patients with cerebrovascular accidents were divided into treatment group and control group. One hundred -and twenty seven patients of the control group received conventional treatment while one hundred and four patients of treatment group received in addition famotidine. Compared the incidence rates of stress ulcer and mortality between the 2 groups. Results:The incidence rates of stress ulcer in treatment group and control group were 22. 11% and 53. 54% respectively. The difference was very significant statistically (P<0. 01). Concludsion ; Addition of famotidine in the treatment of comatous patients with cerebral accidents can decrease the incidence of complicating stress ulcer and mortality.