还原型谷胱甘肽对早期2型糖尿病肾病氧化应激状态的影响

Effect of reduced glutathione on oxidative stress in the patients with type 2 diabetic nephropathy

目的:探讨还原型谷胱甘肽对早期2型糖尿病肾病氧化应激状态的影响。方法:2型糖尿病肾病Ⅲ期患者72例,随机分为:对照组36例,给予常规治疗;治疗组36例,对照组在对照组的基础上加还原型谷胱甘肽治疗,检测相关指标。结果:经还原型谷胱甘肽治疗后,患者hs-CRP、IL-6、TNF-α、Hcy、24hmALB水平明显降低治疗前(P<0.05)。治疗后,治疗组血清炎症标志物hs-CRP、TNF-α、Hcy水平,明显低于对照组,差异有统计学意义(P<0.05)。结论:早期2型糖尿病肾病存在氧化应激状态,还原型谷胱甘肽可改善氧化应激,减少尿mALB排泄。

Objective： To study the effect of reduced glutathione on oxidative stress in the patients with type 2 diabetic nephropathy. Methods： 72 patients with type 2 diabetic nephropathy were en-rolled,of which 36 were put into the control group and the left 36 were in the treatment group ran-domly. Patients in treatment group received reduced glutathione and routine insulin therapy,while patients in control group took routine insulin therapy only. Based on which, the indicators involved would be determined. Results： With the treatment of reduced glutathione, the serum hs-CRP, IL- 6, TNF-a, Hcy level and 24-hour urine microalbumi significantly increased（P〈0.05）. And serum levels of inflammatory markers hs-CRP, TNF-α, Hcy level significantly decreased in treatment group vs the control group（P〈0. 05）. Conclusions： Microinflammation exists in the patients with type 2 diabetic nephropathy, and reduced glutathione can obviously improve the oxidative stress and decreased urinary mALB excretion.