股动脉介入药物灌注术治疗糖尿病足近期及中期疗效观察

Evaluation of short-and mid-term efficacy of femoral artery intervention in treating diabetic foot

目的:观察股动脉介入药物灌注术治疗糖尿病足的近期及中期疗效。方法:70例糖尿病足患者,随机分为传统治疗组和介入治疗组,比较治疗前和治疗1周和6个月后下肢麻、冷、痛的情况及踝肱指数(ABI)、浅感觉震动阈值(VPT)变化。结果:治疗1周和6个月后,介入治疗组下肢麻、冷、痛缓解率高于对照组,治疗1周后两组ABI、VPT与治疗前比较,差异有统计学意义(P<0.05)。治疗6月后,介入治疗组ABI、VPT与治疗前比较,差异有统计学意义(P<0.05)。结论:股动脉介入药物灌注术治疗糖尿病足的近期及中期疗效良好。

Objective： To observe the short-and mid-term efficacy of interventional therapy through femoral artery in treating diabetic foot. Methods： 70 cases patients with diabetic foot were divided into two groups. The control group was treated with traditional comprehensive treatment, while the interventional group with combination of traditional comprehensive treatment and interventional therapy. Before and after treatment, we observed the changes of lower limb symptom （numbness, cold and pain）, ankle brachial index （ABI） and vibration perception threshold （VPT）. Results： 1 week and 6 months after treatment, the remission rate of lower limb symptom （numbness, cold and pain） in the interventional group was significantly higher than the control group （P〈0.05）. For the two groups, at week 1 after treatment, ABI significantly increased and VPT significantly decreased, especially in the intervention group （P〈0. 05）. However, 6 months after treatment, only the interventional group was found increased ABI and decreased VPT （P〈0.05）. Conclusion： The interventional therapy for diabetic foot has better short- and mid-term effect than traditional comprehensive treatment.