苦参素注射液治疗各型湿疹

Kurarinone injection in treating different types of eczema

目的 :探索应用苦参素注射液治疗各型湿疹的临床疗效。方法 :选择各型湿疹病人 10 4人 ,分为苦参素组 62例和葡萄糖酸钙对照组 4 2例 ,分别用苦参素注射液 2 0 0mg ,im ,bid和 10 %葡萄糖酸钙注射液 10mL ,维生素C 1.0 g ,2 5%葡萄糖注射液 2 0mL ,iv ,qd ;2组均以 10d为一个疗程 (各 1～3疗程 )。结果 :经 1～ 3个疗程治疗显示苦参素组的总有效率为 87% ,葡萄糖酸钙对照组的总有效率为 81% (P >0 .0 5) ,2组相比无明显差别 ;但以 2组显效率 (痊愈 +显效 )比较 ,则分别为 66%和 4 3% ,2组相比差别有显著意义 (P <0 .0 5)。苦参素注射液对急性、亚急性湿疹的总有效率为 94 % ,慢性湿疹的总有效率为 79%。与对照组相比差别有显著意义 (均P <0 .0 1) ,从显效率比较 ,急性、亚急性组明显高于慢性。 (P <0 .0 1)。结论 :苦参素注射液对各型湿疹均有较好的疗效 ,对急性、亚急性湿疹的疗效尤为明显。

AIM:To study the clinical effects of kurarinone injection in treating different types of eczema. METHODS: One hundred and four patients with different types of eczema were randomly divided into 2 groups. Kurarinone group of 62 patients (M30, F32; age 43 a± s 9 a) was treated with kurarinone 200 mg, im, bid for 10-30 d and control group of 42 patients (M 22, F 20; age 43 a±7 a) was treated with 10% calcium gluconate 10 mL, vitamin C 1.0 g, 25% glucose injection 20 mL, iv, qd for 10-30 d. The results were compared by statistics of Chi-square test. RESULTS: The total response rates of kurarinone group and control group were 87% and 81% respectively ( P > 0.05), but the remarkable effective rates of kurarinone group and control group were 66% and 43% respectively ( P < 0.05). The total response rate of kurarinone injection on acute and subacute eczema was 94%, while that of it on chronic eczema was 79% ( P <0.01). The remarkable effective rate of kurarinone injection on acute and subacute eczema was significant difference with that on chronic eczema ( P <0.01). CONCLUSION: Kurarinone injection is effective in treating different types of eczema, especially in acute and subacute types.