白芍与川乌配伍前后急性毒性实验研究

ACUTE TOXICITY EXPERIMENT OF WHITE PEONY ROOT AND RADIX ACONITI TOGETHER OR SINGLE USE

以川乌与白芍配伍前后的水煎液分别给小鼠灌胃 ,急性毒性实验结果为 :川乌 L D5 0 16 3.75 7g· kg- 1、乌芍 1∶ 1L D5 0 2 39.332 g· kg- 1 、乌芍 1∶ 2 L D5 0 2 5 0 .380 g· kg- 1 、乌芍 2∶ 1L D5 0 183.189g· kg- 1 ,配伍前后有明显差异 ( P<0 .0 1) ,表明乌芍配伍能降低川乌的毒性 ,但是 ,腹腔注射未出现上述结果。

WT5”BZ]In the experiment,mice were randomly divided into six groups to observe the toxicity experiment of White Peony Root and Radix Aconiti together or single use.In observation groups,group 1 was perfused with single White Peony Root decoction,group 2 with single Radix Acontit,and group 3 5 with Radix Aconiti and White Peony Root together in different proportion,which the ratios of Radix Aconiti to White Peony Root were 1∶1(group3),1∶2(group4),2∶1(group 5)respectively.The results were that LD 50 in guoup 2 5 were 163.757,239 332,250.380 and 183.189 g·kg -1 (P<0.01).It indicated that the toxicity of Radix Aconiti could be reduced remarkably as it was administered with White Peony Root together.But,the above metioned results didn’t reappeared as the two drugs were given through intraperitoneal injection. [