不同人群低剂量美沙酮维持治疗减药量研究

Dose reduction research on low doses of methadone maintenance treatment of different groups

目的:研究不同人群吸毒患者在美沙酮维持治疗中对对美沙酮的依赖性。方法:首先,医生确定患者服用美沙酮初始计量,然后逐步减少美沙酮剂量,直至到达低剂量稳定状态,通过对不同人群美沙酮维持治疗临床数据做t检验得出初始剂量和维持剂量间的差异性。结果:在足量维持治疗后,很多受治者常可以减量至低剂量(<20 mL/日)维持,甚至试停药。并且,根据不同人群用药减量的对比,得出不同人群对美沙酮的不同依赖性。结论:①女性患者相较于男性患者美沙酮用量可减至更低;②年龄越小对美沙酮依赖性相对越小,更可低剂量维持治疗;③吸毒年限越少,美沙酮用量越低。以上结论可以指导医生用药。

Objective：To research on the dependence of methadone in different populations. Methods： First, doctors identify pa- tients＇ initial dose, and then gradually reduce the methadone dose, until she reached a low dose of steady state, then do t test through the different crowd＇s methadone maintenance treatment clinical data to obtain the difference. Results： After sufficient quantities mainte- nance therapy, many of the patients can be tapered to low doses （ 〈 20ml/day）, even withdrawal. In addition, obtained that different people have different dependence of methadone. Conclusion： （1）Female patients ean be reduced to a lower dose than male patients ; （2） Younger can be reduced to lower than older ones ; （3）The less drug use fixed number of year, the lower methadone reduced to. The up- per conclusions can used to guide doctor＇s medication.