三个哌嗪二酮类化合物对Lewis癌体内肺转移的影响

Influence of pulmonary metastasis of three bisdioxopiperazines on Lewis lung carcinomas in vivo

目的 比较吗丙嗪 (Pro) ,乙双吗啉 (Bim)和丙亚胺(Raz)对动物肿瘤肺转移的影响。方法 用生物接种法进行Lewis癌肺转移的观测。结果 Pro和Bimd 2起给药和d 8起给药对Lewis癌肺转移均有抑制 ,Raz仅d 2起给药对Lewis癌肺转移有影响 ,Pro在等毒性剂量下对Lewis癌肺转移疗效优于Bim。结论 Pro的抗Lewis癌肺转移疗效优于Raz可能是由于其存在新的分子药理机制。

AIM To compare the effects of probimane( Pro), bimolane ( Bim) and razoxane( Raz) on animal tumor metastasis in vivo . METHODS A biological inoculation method for assessment of pulmonary metastasis of Lewis lung carcinoma(3LL) was employed. RESULTS Pro and Bim inhibited the pulmonary metastasis of 3LL both from d 2 and from d 8 injections, but Raz only inhibited the pulmonary metastasis of 3LL from d 2 injections. Pro inhibited the pulmonary metastasis of 3LL more potently than Bim did at equitoxic dosage. CONCLUSION Pro is better in the treatment of pulmonary metastasis of 3LL than Raz for its possible novel molecular mechanisms.