促红细胞生成素治疗新生儿缺氧缺血性脑病32例临床分析

Clinical Analysis of 32 Neonates with Hypoxic-ischemic Encephalopathy Treated by Erythropoietin

目的:探讨促红细胞生成素(EPO)治疗新生儿缺氧缺血性脑病(HIE)的疗效和安全性。方法:将生后72 h内的中重度HIE患儿32例随机分为对照组和治疗组各16例,对照组按常规治疗,治疗组另给予EPO500 U/(kg·次),每周3次,共2周,比较两组生后7d、14d、28d新生儿行为神经评分(NBNA)。结果:与对照组比较,治疗组生后7 d、14 d、28 d的NBNA评分及格者明显增多,治疗过程中患儿无明显不良反应。结论:EPO可促进HIE患儿神经功能的早期恢复,且对其它系统无不良影响。

Objective ：To explore the clinical effect and safety of neonatal hypoxic - ischemic encephalopathy （HIE） treated by erythropoietin （EPO）. Methods： 32 neonates with HIE were randomly divided into control group and treatment group, and each group was 16 cases. The treatment group was treated by EPO with the dosage of 500 U/（kg .dose）,three times a week for 2 weeks based on the control group treated by routine methods. Neonatal behavioral neurological assessment （NBNA） was evaluated and compared at treatment 7 d, 14 d and 28 d between the two groups. Results： Compared with the control group, scoring of NBNA were significantly higher at all evaluation times （P〈0.05）. There were no obvious adverse reactions during the therapeutic process. Conclusion： It can promote neurological recovery early for neonate with HIE treated by EPO, but it has no bad effect on other systems.