清热祛痰汤治疗老年慢性阻塞性肺疾病的临床研究

Clinical Study on Qingrequtan Decoction in Treating Chronic Obstructive Pulmonary Disease Among Aged Patients

目的:观察清热祛痰汤治疗老年慢性阻塞性肺疾病急性加重期(AECOPD)的临床疗效。方法:选取我院呼吸科住院AE-COPD患者120例采用随机数字表法随机分为观察组与对照组各60例,2组患者均给予常规治疗包括抗生素、支气管舒张剂、吸氧、对症治疗等,观察组加用自拟清热祛痰汤加减治疗,每日1剂,分早晚两次服用。2组患者以连续治疗14d为1个疗程,比较临床疗效。结果:治疗1个疗程后,观察组总有效率明显高于对照组(χ2=10.457,P<0.01),具有统计学意义。2组患者治疗前各项症状、体征积分、FEV1%、FEV1/FVC与呼吸困难指数比较差异无统计学意义(P>0.05),治疗后各项指标均较治疗前有明显改善(P<0.01),但观察组较对照组改善明显(P<0.01),具有统计学意义。结论:清热祛痰汤治疗老年慢性阻塞性肺疾病急性加重期(AECOPD)效果理想,可显著改善临床症状、体征及肺功能状态,值得推广应用。

Objective： To observe the clinical efficacy of Qingrequtan decoction treating acute exacerbations of chronic obstructive pulmonary disease （ AECOPD） among aged people. Methods： One hundred and twenty AECOPD patients admitted to Respiratory Department of our hospital were selected and randomly divided into observation group （n=60） and control group （n=60） using a random number table. Patients in both groups were given conventional treatment,including antibiotics,bronchodilators,oxygen,and other treatment in light of symptoms. Patients in observation group received extra treatment of modified Qingrequtan decoction,one dosage a day, divided into two parts for morning administration and evening administration. One treatment course consisted of 14 continuous days of treatment,and clinical efficacy were compared. Results： After a course of treatment,the total effective rate in observation group was significantly higher than that in the control group （χ2 = 10. 457,P0.01） ,with statistical significance. There were no significant differences between the two groups in terms of symptoms,sign score,FEV1% and FEV1 / FVC and dyspnea index of the patients before the treatment （P 0. 05） . There were obvious improvement of the indexes after treatment in both groups,and the observation group showed better improvement compared with the control group （P0.01） . Conclusion： Qingrequtan decoction treating acute exacerbations of chronic obstructive pulmonary disease （ AECOPD） among aged people shows satisfactory therapeutic effect in improving clinical symptoms,signs and pulmonary function,which is worth generalizing.