丹红注射液联合西药对糖尿病周围神经病变神经传导速度及神经生长相关因子的影响观察

Observation on the Influence of Danhong Injection Combined with Western Medicine on Nerve Conduction Velocity and Nerve Growth Related Factors of Diabetic Peripheral Polyneuropathy

目的:探讨丹红注射液联合西药对糖尿病周围神经病变神经传导速度及神经生长相关因子的影响。方法:选取2010年7月至2012年9月于本院采用常规西药进行治疗的41例糖尿病周围神经病变患者为对照组,同期采用丹红注射液联合常规西药进行治疗的41例患者为治疗组,后将2组患者治疗前及治疗后10d、20d的神经传导速度及神经生长相关因子水平进行比较。结果:治疗组治疗后10d及20d的正中神经、腓总神经的神经传导速度均高于对照组,血清MBP低于对照组,BDNF、NGF及IGF-1均高于对照组,P均<0.05,均有统计学意义。结论:丹红注射液联合西药可有效改善糖尿病周围神经病变患者的神经传导速度及神经生长相关因子,对于改善患者的神经功能发挥着积极的临床作用。

Objective： To study the influence of Danhong injection combined with western medicine on the nerve conduction velocity and nerve growth related factors of diabetic peripheral polyneuropathy. Methods： Forty-one patients with diabetic peripheral polyneuropathy who were treated with routine western medicine in our hospital from July 2010 to September 2012 were selected into control group,and another 41 patients who were treated with Danhong injection combined with western medicine at the same time were selected into treatment group,then the nerve conduction velocity and nerve growth related factors of patients in the two groups before and after the treatment at tenth and twentieth day were compared. Results： The medium nerve and common peroneal nerve conduction velocity of patients in treatment group after the treatment at tenth and twentieth day were all higher than those of control group,and serum MBP were lower than those of control group,serum BDNF,NGF and IGF-1 were all higher than those of control group,（ P 0. 05） there were all significant differences between the two groups. Conclusion： The Danhong injection combined with western medicine can effectively improve the nerve conduction velocity and nerve growth related factors of patients with diabetic peripheral polyneuropathy,so it plays an active clinical role in improving the nerve function of patients.