自拟消脂方治疗非酒精性脂肪性肝炎的42例临床观察

Clinical Effect on Xiao Zhi Prescription Treating 42 Cases of Non-alcoholic Steatohepatitis

目的:观察自拟消脂方治疗非酒精性脂肪性肝炎(Non-alcoholic steatohepatitis,NASH)的临床疗效。方法:将我科收治的80例非酒精性脂肪性肝炎患者随机分为对照组和治疗组,对照组予西药治疗,治疗组在此基础上加用中药消脂方治疗,观察2组患者的总体疗效、实验室指标改善情况,并随访6个月观察复发情况。结果:治疗组总有效率为95.24%优于对照组的78.95%,治疗组患者ALT、AST、GGT、TG改善情况均优于对照组,差异均有统计学意义(P<0.05):治疗组复发率5.00%低于对照组的24.14%,差异有统计学意义(P<0.05)。结论:自拟消脂方治疗非酒精性脂肪性肝炎具有疗效好、复发率低等优点,无明显不良反应,值得临床推广应用。

Objective： To observe the clinical effect of self made Xiao Zhi Prescription treating non-alcoholic steatohepatitis. Methods： Eighty non-alcoholic steatohepatitis patients admitted to our department were randomly divided into treatment group and control group. Patients in control group were given western medicine,and patients in treatment group received extra TCM treatment of Xiao zhi prescription. The total therapeutic effect,and lab parameters changes were observed. And follow-up was conducted 6 month after the treatment to see the relapse rate. Results： The total effective rate in treatment group was 95. 24% ,which was significantly better than the 78. 95% in the control group （P0.05） ; the improvement of ALT,AST,GGT,TG in treatment group were significantly better than that of the control group （P0.05） ; the recurrence rate of the control group was 24. 14% ,while that in the treatment group was 5. 00% , which showed significant differences （P0.05） . Conclusion： Xiao Zhi Prescription treating NASH has good efficacy and low recurrence rate with no obvious adverse reactions,which is worthy of clinical application.