舒芬太尼用于小儿手术麻醉的临床研究

Sufentanil for Anesthesia of Pediatric Clinical Operation

目的观察不同剂量的舒芬太尼在小儿耳鼻喉手术的镇痛作用,并探讨其安全性。方法选择ASAI～Ⅱ级60例进行耳鼻喉手术的患儿,随机分为舒芬太尼1组、舒芬太尼2组和舒芬太尼3组,每一组20例。分别给予0.04μg(/kg h)、0.05μg(/kg h)、0.06μg(/kg h)的舒芬太尼。观察手术各时点镇痛、镇静效果评分、血氧饱和度(SpO2)和不良反应的发生情况。结果镇痛效果的评分:1组各时点镇痛效果明显高于2组、3组,差异有统计学意义(P<0.05);镇静效果评分:1组各时点镇静效果明显低于2组、3组,差异有统计学意义(P<0.05,P<0.01);不良反应:3组有4例术后出现昏睡,与2组、3组比较,差异有统计学意义(P<0.05),三组SpO2比较无统计学意义(P>0.05)。结论 0.05μg/(kg h)的舒芬太尼用于小儿耳鼻喉手术的镇痛和镇静更有效。

Objective To observe the analgesic effect of different doses of sufentanil in children otorhinolaryngologic operation, and to discuss its safety. Methods ASA was performed in 60 patients with I- II ENT operation were randomly divided into 1 groups, sufentanil, sufentanil group 2 and sufentanil 3 groups, eaich group of 20 eases. They were treated by 0.04μg/（kg.h）, 0.05μg/（kg.h）, 0.06μg/（kg.h） sufentanil. To observe the analgesic, sedative effect of operation at the score, blood oxygen saturation （SpO2） and adverse drug reaiction. Results The score of the analgesic effeict of 1 group were significantly higher in the 2 group, the analgesic effect of 3 groups, the difference was statistically signifiicant （P〈0.05）; sedation score： 1 group was signifiicantly lower than that in group 2, the sedative effects of 3 groups, the difference was statistically significant （P〈0.05, P〈0.01）; adverse reaction： 3 group 4 eases of postoperative lethargy, and the 2 group, the 3 groups, the difference was statistically significant （P〈0.05）, SpO2 of three groups were not significant （P〉0.05）. Conclusion the 0.05μg/（kg.h） of sufentanil in pediatric ENT operation more effective analgesic and sedative.