血清P-LAP、镁、胰岛素抵抗与早产的相关性研究

Study on the Correlation between Serum P-LAP, Magnesium, Insulin Resistance and Premature Delivery

目的探讨血清P-LAP、镁、胰岛素抵抗与早产的相关性,以为早产的监测及干预提供依据。方法选取2010年6月至2013年1月本院的82例早产孕妇为观察组,同期的82例正常妊娠孕妇为对照组,然后将两组孕妇的血清P-LAP、镁及胰岛素抵抗相关指标进行比较,并将上述指标与早产的相关性进行研究分析。结果观察组的血清P-LAP及镁水平均低于对照组,OGTT实验不同时间血糖、HOMA-IR高于对照组,IAI及QUICKI低于对照组,且观察组中早产者上述指标波动大于先兆早产者,P均<0.05,均有显著性差异,且血清P-LAP、镁、胰岛素抵抗均与早产有明显的相关性。结论血清P-LAP、镁、胰岛素抵抗与早产的相关性较为明显,为早产的监测及干预措施的制定提供了依据。

Objective To study the correlation between serum P-LAP, magnesium, insulin resistance and premature delivery, in order to provide the evidence for the monitoring and intervention of premature delivery. Methods 82 pregnant women with premature delivery in our hospital from June 2010 to January 2013 were selected as observation group, and 82 normal pregnant women at the same time were selected as control group, then the serum P-LAP, magnesium and insulin resistance related indexes of two groups were compared, and the correlation between those indexes and premature delivery were studied and analyzed. Results The serum P-LAP and magnesium of observation group were all lower than those of control group, blood glucose of OGTT test at different times and HOMA-IR were all higher than those of control group, IAI and QUICKI were lower than those of control group, and those indexes fluctuation of pregnant women with premature delivery in observation group were bigger than those with threatened premature labor, all P〈0.05, while there were obvious correlation becween the serum P-LAP, magnesium, insulin resistance and premature delivery. Conclusion The correlation between serum P-LAP, magnesium, insulin resistance and premature delivery is obvious, and it provides evidence for the monitoring and intervention of premature delivery.