盐酸丙帕他莫不同用药时机对术后镇痛的影响

Effect of Different Time Administration of Propacetamol hydrochloride on Postoperative Analgesic Efficacy in Patients Undergoing Operations

目的探讨盐酸丙帕他莫不同给药时机对手术患者术后镇痛效果的影响。方法择期腹部手术患者60例,随机分为A和B组(n=30)。A组切皮前15min静脉滴注2g盐酸丙帕他莫,B组术毕前15min静脉滴注2g盐酸丙帕他莫。两组患者术后48h内均使用舒芬太尼行自控静脉镇痛(PCIA)。术后随访,记录术后12h和24h患者PCIA的按压次数,及术后2、4、6、12、24h的疼痛视觉模拟(VAS)评分。结果与B组相比,A组术后12h和24h PCIA按压次数明显减少(P<0.05),且术后2、4、6、12h VAS评分显著降低(P<0.05)。两组患者24h VAS评分无统计学差异(P>0.05)。结论腹部手术超前应用盐酸丙帕他莫,能有效提高患者术后镇痛效果,减少舒芬太尼的用量。

Objective To investigate the effect of different time administration of Porpacetamol hydrgqhloride on the postoperative analgesic efficacy in patients undergoing abdominal operations. Methods Sixty patients undergoing abdominal surgery were randomly allocated to A and B groups（n=30 each）. Group A received iv Porpacetamol hydrgqhloride 2g at 15 min before skin incision while group B received iv Porpacetamol hydrgqhloride 2g at 15 min before the end of operation. All the patients received patient-controlled intravenous analgesia with sufentanil. All the patients were followed up after operation. The times of PCIA in 12h and 24h post-operation, VAS score at the time of2h, 4h, 6h, 12h, 24h post-operation were recorded. Results Compared with group B, the times of PCIA in 12h and 24h post-operation was significantly reduced and VAS score at the time of 2h, 4h, 6h, 12h, post-operation decreased in group A （P〈0.05）. There was no significant difference in VAS score at the time of 24h between the two groups （P〉0.05）. Conclusion Porpacetamol hydrgqhloride preemptive analgesia in patients undergoing abdominal operations can assist the postoperative analgesic efficacy and reduce the sufentanil consumption.