己酮可可碱在烧伤治疗中的研究进展

Research advancement on pentoxifylline in treatment on burns

烧伤仍是困扰人类的一大顽疾之一,在过去的十几年里,烧伤治疗水平得到了长足进步。本文就国内外关于己酮可可碱对烧伤治疗的各个方面,包括烧伤后瘢痕、菌群移位、各主要脏器功能障碍等方面的研究进行综述与回顾,以期为临床治疗烧伤提供一个新的思路。

Despite of development of care and rehabilitation, bums still remain a health-threatening problem. Significant and consistently positive body of evidences from animal and human studies of thermal injury support the use of pentoxifylline as a adjunct of treating smoke inhalation injury, acute respiratory distress syndrome and acute lung injury, improving the breakdown of intestine barrier, maintaining the hemorheologic and microvascular stability, and have some potential benefits on the prevention of hypertrophic scar proliferation post bum injury. This paper attempts to give an overview of the current knowledge via literature review on the effects of pentoxifylline in the management of burns. It seems that pentoxifylline shows a potential adjunct in bum management.