摘要
以氯高铁血红素为原料 ,经脱铁、酯化一步得原卟啉二甲酯粗品。该粗品经甲苯处理纯化后 ,用氢氧化钠皂化得 98%以上纯度的原卟啉钠。总收率 91.5 %。
An improved preparation of protoporphyrin disodium from hemin is described. Esterification of hemin, while the iron was removed, gave crude protoporphyrin dimethyl ester which was purified in toluene and then saponified by sodium hydroxide. The purity of protoporphyrin disodium obtained was over 98% by HPLC in overall yield of 91.5%.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2000年第7期293-294,共2页
Chinese Journal of Pharmaceuticals
关键词
原卟啉钠
保肝药
制备
氯高铁血红素
protoporphyrin disodium
hepatoprotective drug
preparation
hemin
