摘要
目的 :对动脉栓塞阿霉素明胶微球 (ADM GMS)的制备工艺及特性进行初步研究。方法 :以生物降解材料明胶为载体 ,采用乳化化学交联法制备含阿霉素的明胶微球 ,并进行家兔胃左动脉栓塞 ,分别于术后 1周至 4周内作栓塞观察。结果 :所制备的阿霉素明胶微球外形圆整 ,平均粒径为 6 2 .74μm ,载药量为2 1.78μg·mg-1,包封率为 6 7.43% ,体外释药和动物胃左动脉栓塞基本符合要求。结论 :阿霉素明胶微球有望成为临床用动脉栓塞术治疗胃癌的新给药制剂。
OBJECTIVE:To study the preparation technique of adriamycin(doxorubicin) gelatin microspheres(ADM GMS) for artery embolization and their characteristics.METHODS:ADM GMS were prepared by using gelatin as core material and emulsion chemical crosslinking method.The embolization efficiency was observed during 4 weeks after the operation of embolizing the left gastric artery in rabbits.RESULTS:ADM GMS was regular in morphology with a mean diameter of 62.74 μm.The loading amount of adriamycin was 21.78 μg·mg -1 and encapsulation efficiency was 67.43% .The biodegrading and release characteristics in vitro and enbolizing for the left gastric artery in rabbits could basically meet requirements.CONCLUSIONS:Adriamycin gelatin microspheres hopefully could be one of the new administration dosage form for gastric cancer by embolizing techniques.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2000年第7期387-389,共3页
Chinese Journal of Hospital Pharmacy
基金
山西省科委资助!项目 (编号 962 1 1 3)
关键词
阿霉素
明胶微球
乳化化学交联法
体外溶出
doxorubicin
gelatin microspheres
emulsion chemical crossline method
releasing in vitro