喷雾干燥法制备阿司匹林肠溶微囊的实验研究

Study on preparation of enteric microcapsules of aspirin by spray drying

目的 :采用喷雾干燥法制备阿司匹林肠溶微囊 ,建立微囊质量评价方法。方法 :采用丙烯酸树脂Ⅱ号为包衣材料 ,篦麻油为增塑剂 ,乙醇为溶剂 ,阿司匹林为囊心物 ,将囊材与囊心物按 1∶2和 1∶4的比例喷雾干燥制成微囊。结果 :经扫描电镜和差示量热扫描法测定表明 ,微囊包裹形成。囊心物∶囊材按 1∶4较好 ,微囊能迅速在人工肠液中释放 ,45min释药达到 75 % ,肠溶片 45min释药低于 6 0 %。结论 :喷雾干燥法制备肠溶微囊 ,方法简单 ,工艺稳定 ,改变丙烯酸树脂Ⅱ号比例可控制药物释放速率。

OBJECTIVE:To prepare enteric microcapsules of aspirin by spray drying technique.METHODS:Spray drying using eudragit Ⅱ as coating material,castor oil as plasticizers,alcohol as solvent where the drug was dissolved as the ratio to coating material was 1∶2 and 1∶4.RESULTS:The microcapsules were characterized by scanning electron microscopy(SEM) and differential scanning calorimetry(DSC).The release of microcapsules(1∶4) was 75 percent in artificial intestinal juice within 45 min.Meanwhile,only less than 60 percent of enteric coated tablet release was obtained.CONCLUSIONS:Spray drying is a simple method with a reliability process,the released rate of microcapsules can be controlled by changing the ratiot of Eudragit Ⅱ.