表皮生长因子受体2在胃癌组织中的表达及意义

Expression and clinical significance of HER-2 in gastric carcinoma tissues

目的探讨表皮生长因子受体2(HER-2)在胃腺癌组织中的表达及其与胃癌各临床病理特征的关系。方法应用免疫组织化学(PV-9000)方法检测90例胃癌组织中的HER-2蛋白的表达,并对HER-2的蛋白不同表达水平与胃腺癌各临床病理学特征进行分析。结果胃腺癌组织中HER-2蛋白阳性表达率为14.4%(13/90);HER-2蛋白表达与患者的性别无关;年龄≥65岁者阳性表达率(23.8%)高于年龄<65岁者(6.3%);低分化腺癌组阳性表达率(27.3%)高于高中分化腺癌(8.2%);Ⅲ、Ⅳ期(22.2%)阳性表达率高于I、Ⅱ期(2.8%),有区域淋巴结转移的阳性表达率(21.7%)高于无区域淋巴结转移者(6.8%),肿瘤直径≥5cm的阳性表达率(23.7%)高于肿瘤直径<5cm(7.7%),以上各组之间差异均有统计学意义(均P<0.05)。结论 HER-2蛋白表达与年龄、分化程度、分期、肿瘤大小及区域淋巴结有相关性,提示HER-2在胃癌的发生发展中可能起重要作用。

Objective To investigate the expression and clinical significance of HER-2 in gastric carcinoma.Methods The expression of HER-2 in the tumor tissue from 90 patients with gastric carcinoma was examined by immunohistochemically methond.The relationship between HER-2 expression and the clinical pathologic parmeters was analyzed.Results The positive rates of HER-2 in gastric carcinoma was14.4%（13/90）.The expression of HER-2 was more frequently detected in the age ≥65 than in the age65.The expression of HER-2 was more frequently detected in the low differentiation than in the high differentiation.The expression of HER-2 was more frequently detected in the Ⅲ and Ⅳ stage than in the I and Ⅱstage.The expression of HER-2 was more frequently detected in the gastric carcinoma with regional lymph metastasis than without regional lymph metastasis.The expression of HER-2 was more frequently detected in gastric cancer with carcinoma diameter≥5 cm than that with carcinoma diameter5cm,all groups were significant different（p0.05）.Conclusions The expression of HER-2 was significantly correlated with the clinicopathological factors such as diameter、differentiation、stage and regional lymph metastasis.HER-2 may play important roles in development of gastric carcinoma.