依那普利叶酸片治疗非ST段抬高急性心肌梗死PCI术后的疗效观察

Observation of Enalapril Folic Acid Tablets Treatment of Non-ST Segment Elevation Acute Myocardial Infarction Patients After PCI

目的:观察马来酸依那普利叶酸片(简称依叶)治疗非ST段抬高急性心肌梗死PCI术后的疗效是否优于马来酸依那普利片。方法:选择NSTEMI患者经三级医院PCI治疗后再转入我院后续治疗的50例为实验组,对照组为既往在我院接受治疗的患者50例,实验组口服依那普利叶酸片10mg/d,对照组单一依那普利片10mg/d口服,持续3个月～1年;观察两组患者治疗前、后血浆HCY、血压、血糖对比,治疗前、后做常规18导联心电图,观察18导联上ST段压低总和。结果:在ST段改善方面,实验组比对照组改善明显;在心衰发生情况方面,实验组7例出现心衰,占14.0%,对照组16例出现心衰,占32.0%;在死亡率方面,实验组3例死亡,发生率为6.0%,对照组6例死亡,发生率为12.0%,三项比较均具有统计学意义(P<0.05)。两组在治疗前、后的组内、组间比较血浆HCY具有统计学意义(P<0.05)、血压在治疗前、后的组内比较均具有统计学意义(P<0.05),而在组间比较无统计学意义(P>0.05),血糖在治疗前、后的组内、组间比较均无统计学意义(P>0.05)。结论:依那普利叶酸片治疗非ST段抬高急性心肌梗死PCI术后,后续治疗方面具有改善心肌缺血、降压和降HCY水平效果显著,同时还可以减少心衰等并发症及死亡率。

Objective：Observation of enalapril maleate and folic acid tablets（hereinafter referred to as leaf）the effect of treating non-ST segment elevation acute myocardial infarction patients after PCI is better than that of enalapril maleate tablets.Methods：Patients with NSTEMI grade three hospital after PCI therapy to 50cases in our hospital followup treatment,control group 50cases of patients treated in our hospital,the experimental group,enalapril folic acid tablets 10mg/d,while the control group only enalapril 10mg/d orally,for 3months to 1year;two groups were observed before and after patients treated with plasma HCY,blood pressure,blood sugar comparative before and after treatment,routine 18lead ECG,observation of 18lead ST segment depression sum.Results：The improvements in the ST segment,the experimental group was significantly better than the control group improved;in heart failure,7cases in the experimental group had heart failure,accounting for 14.0%,16cases in the control group had heart failure,accounting for 32.0%;in terms of mortality,experimental group 3cases died,the incidence rate was 6.0%,the control group of 6cases of death,the incidence rate was 12.0%,three were statistically significant（P0.05）.The two groups before and after treatment group,compared with plasma HCY with statistical significance（P0.05）,blood pressure before and after treatment were compared with the group with statistical significance（P0.05）,but no statistical significance in the group（P0.05）,blood glucose before and after treatment in the group,the comparison among groups had no statistical significance（P0.05）.Conclusion：Enalapril folic acid tablets in treatment of non-ST segment elevation acute myocardial infarction after PCI,the follow-up treatment can improve myocardial ischemia,reduction of blood pressure and HCY level significantly,but also can reduce the complications and mortality in heart failure.