维生素D缺乏与喘息性支气管炎发病的关系

Relationship between Deficiency of Vitamin D and the Incidence of Asthmatic Bronchitis

目的:通过喘息性支气管炎患儿血清25-羟基维生素D水平的测定,探讨血清维生素D水平与喘息性支气管炎发病的关系,为小儿喘息性疾病的治疗提供新的理论和临床依据。方法:选择儿科门诊喘息性支气管炎患儿80例,随机分为VitD治疗组和非VitD治疗组,以同期健康体检儿30例作为对照组。采用液相色谱串联质谱技术检测血清25-羟基维生素D水平;同时记录喘息性支气管炎患儿临床症状的缓解时间以及半年喘息再发次数。结果:(1)治疗前VitD治疗组较对照组血清25-羟基维生素D水平低,2组比较差异均有统计学意义(P<0.01)。(2)VitD治疗组较非VitD治疗组临床症状的缓解较快,半年喘息再发次数较少,2组比较差异均有统计学意义(P<0.05)。结论:VitD缺乏与喘息性支气管炎发病密切相关,可能是喘息性支气管炎的潜在病因。在喘息性支气管炎的治疗过程中,补充VitD可及时缓解临床症状,降低喘息再发率。

Objective：By measuring children with asthmatic bronchitis serum 25-hydroxy vitamin D levels,and to explore the relationship between serum vitamin D levels and incidence of asthmatic bronchitis,and provide a new theoretical and clinical basis for the treatment of asthmatic disease.Methods：80cases of pediatric outpatient children with asthmatic bronchitis,were randomly divided into the VitD treatment group and the non-VitD treatment group.Healthy children during the same period 30cases（control group）as a control.By liquid chromatography-tandem mass spectrometry to detect serum 25-hydroxyvitamin D levels;simultaneously record the duration of remission of clinical symptoms,as well as six months,the number of respite recurrence.Results：VitD tveatmert group compared with the control group serum 25-hydroxy D levels were statistically significant difference（P0.01）.VitD treatment group compared with non-rapid remission of clinical symptoms of VitD treatment group,six months respite recurrence less frequently,two group differences were statistically significant（P0.05）.Conclusion：The VitD lack is closely related to the pathogenesis of asthmatic bronchitis,may be the underlying cause of asthmatic bronchitis.Asthmatic bronchitis treatment process,the supplement VitD alleviate clinical symptoms,reduce respite recurrence rate.