绝经女性人体学指标与超声骨密度的关系分析

Analysis on Relationship between Anthropometric Measurements and Quantitative Ultrasound Indexes of Bone Quality of Post-menopause Women

目的:旨在讨论人体测量学指标、糖脂代谢、雌二醇与超声骨密度指标的相关性。方法:随机抽取本地社区130名自然绝经健康女性,测量其人体学指标,如身高、体重、腰围和臀围,计算体重指数(BMI),并检测其空腹血糖、血脂、胰岛素及雌二醇;使用定量超声骨密度仪测量其右侧跟骨,指标为声速(Speed Of Sound,SOS)、传播指数(Transmis-sion Index,TI)及骨超声评价指数(Osteo Sono-assessment Index,OSI),观察指标间的相关性。结果:(1)腰围与体重、臀围和BMI有良好的相关性(r=0.771、0.779、0.788,P<0.01);臀围与体重和BMI有良好的相关性(r=0.853,0.803,P<0.01),与身高有相关性(r=0.256,P=0.003);(2)年龄与SOS、TI和OSI有负相关性(r=-0.262、-0.188和-0.378,P<0.05);(3)身高在各超声骨密度指标分组中无统计学意义(χ2OSI=1.255,χ2TI=4.913,χ2SOS=1.241,P>0.05);年龄在TI和SOS分组中无统计学意义(χ2=15.997、5.254,P>0.05);体重、腰围、臀围和BMI在OSI、TI分组中有统计学意义(χ2>9.400,P<0.05),而在SOS分组中无统计学意义(χ2<3.000,P>0.05);(4)空腹血糖、总胆固醇、甘油三酯、低密度脂蛋白、空腹胰岛素、HOMO-IR与超声骨密度各指标均无相关性(P>0.05),SOS与雌二醇、高密度脂蛋白有一定相关性(r=0.259,0.199,P<0.05)。结论:骨密度随着年龄的增长而呈现进行性下降,绝经女性在保持糖脂代谢正常的情况下,维持脂肪合理分布,加强肌肉和一定强度的锻炼,适当增加诸如BMI、体重等,可能有益于延缓绝经女性骨质疏松。

Objective：To demonstrate the relationship between anthropometric indexes,glucolipid metabolism,estradiol and the indexes of bone mineral density by qualitative ultrasound（QUS）.Methods：130post-menopause women in local some communities were randomly chosen.They were measured with height,weight,waistline,hip circumference,body mass index and made blood test,including fasting plasma glucose,blood fat,insulin and estradiol.Speeds of sound（SOS）,transmission index（TI）and osteo sono-assessment index（OSI）were measured by quantitative ultrasound（QUS）of right calcaneus.Results：There were good correlations between waistline,weight,hip circumference and BMI（r=0.771,0.779,0.788,P0.01）.There were good correlations between hip circumference,weight,BMI and height（r=0.853,0.803,0.256,P0.01）.The difference of height in all indexes groups of QUS was not statistically significant（χ2OSI=1.255,χ2TI=4.913,χ2SOS=1.241,P0.05）,of age in the TI and the SOS groups was also same（χ2=15.997,5.254,P0.05）.The difference of height,waistline,hip circumference and BMI in the OSI and the TI groups were statistically significant（χ29.400,P0.05）,but in the SOS groups were opposite（1.000χ23.000,P 0.05）.There were not correlations between fasting plasma glucose,total cholesterol,triglyceride,low density lipoprotein,insulin,HOMO-IR and the indexes of QUS（P0.05）,but SOS was interrelated with estradiol and high density lipoprotein（r=0.259,0.199,P0.05）.Conclusion：Bone mineral density is declined with ageing.It might be useful for prevention of osteoporosis of the post-menopause to keep the normal glucolipid metabolism,maintain sound fat distribution,strengthen muscles and reasonably raise the BMI,weight and so on.