缓激肽B2受体基因多态性在膝骨关节炎发生和发展中的作用

Bradykinin B2 receptor polymorphisms contribute to the susceptibility and severity of knee osteoarthritis

目的研究缓激肽B2受体(BDKRB2)基因多态性对膝骨关节炎易感性和严重性的影响。方法在原发性膝骨关节炎245例(观察组)及健康志愿者264例(对照组)中,针对BDKRB2基因多态性-58T/C和+9/-9,分别进行基因型测定。结果 +9/-9基因多态性的基因型分布和等位基因频率,在两组之间存在明显差异。回归分析显示-9/-9基因型相对于+9/+9基因型,罹患膝关节骨关节炎的风险明显增高(OR=2.354,P<0.01)。同时,+9/-9基因多态性与骨关节炎的放射学分型存在相关性,-9等位基因可能与骨关节炎的严重程度有关。-58T/C基因多态性与骨关节炎的易感性和严重性无相关性。结论缓激肽B2受体基因多态性+9/-9可能成为检测骨关节炎易感性和严重性的基因标记物。

Objective To study the effect of bradykinin B2 receptor polymorphisms on the susceptibility and severity of knee osteoarthritis.Methods A total of 245 patients with primary knee OA and 264 healthy volunteer were recruited.BDKRB2 gene polymorphisms,-58T / C and ＋ 9 /-9 polymorphisms,were genotyped.Results The genotype distributions and allele frequencies of ＋ 9 /-9 polymorphisms significantly differed between OA and control subjects.Logistic regression analysis showed carriers with-9 /-9 genotype had a significantly increased risk for knee OA compared with the ＋ 9 / ＋ 9 genotype（OR = 2.354,P ＆lt; 0.001）.The ＋ 9 /-9 polymorphisms also determined the OA radiographic severity.The presence of-9 was associated with severer OA.The-58T / C polymorphisms did not affect OA risk and severity.Conclusion The ＋ 9 /-9 polymorphisms of BDKRB2 gene may be used as a genetic marker for the susceptibility and severity of OA.