苏拉明对大鼠低氧性肺动脉高压的影响

Effects of suramin of the hypoxic pulmonary hypertension in rats

目的 探讨血管内皮生长因子 (VEGF)在低氧性肺动脉高压发病中的作用。方法 将 30只 Wistar大鼠分为对照组、低氧组和低氧 +苏拉明组 ,以常压低氧复制大鼠肺动脉高压模型 ,采用微导管法测定肺动脉平均压 ,对肺组织切片进行图象分析。结果 经低氧 3周后 ,大鼠形成明显的肺动脉高压、肺小动脉管壁增厚和右心室肥厚 ;经苏拉明处理 ,可明显减轻低氧所致的肺动脉压升高、肺血管壁增厚和右心室肥厚。结论 慢性低氧导致肺动脉高压与 VEGF有密切的关系 ,苏拉明可抑制 VEGF的作用而具有显著预防低氧所致肺动脉高压的效应。

Objective To investigate the role of vascular endothelial growth factor (VEGF) in hypoxic pulmonary hypertension and the preventing effcets of suramin,aVEGF antagonist.[WT5”HZ]Methods [WT5”BZ]Thirty male Wistar rats were divided into three groups and expsed to air,to isobaric hypoxia,and to isobaric hypoxia plus suramin,respectively for 3 weeks.The pulmonary arterial pressure was measured by right cardiac catheterization.Histologic sections of the lungs were examined by a computerized image analyser.Results After hypoxic treatment for 3 weeks,the pulmonary artery pressure and the thickness of wall of arteriole were significantly increased,and right ventricular hypertrophy was developed.Chronic suramin treatment effectually prevented the developments of pulmonary hypertension,thickening of pulmonary arteriole and right ventricular hypertrophy induced by hypoxia.[WT5”HZ]Conclusion [WT5”BZ]VEGF plays a role in the process of hypoxic pulmonary hypertension,and suramin can prevent hypoxic pulmonary hypertension.