左氧氟沙星和头孢克罗治疗慢性阻塞性肺病下呼吸道感染的对比观察

A randomized controlled study of levofloxacin and cefaclor in the treatment of lower respiratory tract infections of patients with chronic obstructive pulmonary diseases.

目的 为了评价左氧氟沙星对慢性阻塞性肺病下呼吸道感染的治疗作用。方法 将 6 2例慢性阻塞性肺病下呼吸道感染患者 ,随机分为两组。治疗组 35例 ,采用左氧氟沙星 0 .2 g口服 ,每日 2次 ;对照组 2 7例 ,采用头孢克罗0 .2 5 g口服 ,每日 3次 ,两组疗程均为 7天。结果 左氧氟沙星治疗组的总有效率为 88.6 % ,细菌清除率为 85 .7% ;头孢克罗治疗组的总有效率为 85 .2 % ,细菌清除率为 86 .7%。两组相比差异无显著性 (P>0 .90 )。两组患者共分离出病原菌43株 ,对左氧氟沙星敏感者占 83.7% ,对头孢克罗敏感者占 88.4%。治疗过程中不良反应 ,两组患者均较轻微。

Objective[WT5”BZ] To study the therapeutic effects of levofloxacin in treating severe lower respiratory tract infections of patients with chronic obstructive pulmonary diseases.[WT5”HZ]Methods [WT5”BZ]Sixtytwo patients with chronic obstructive pulmonary diseases and lower respiratory tract infections were randomly divided into two groups.One group (35 patients)was treated with levofloxacin 0.2g ,po,bid for 7 days.The other group(27 patients)was treated with cefaclor 0.25g ,po,tid for 7 days.[WT5”HZ]Results [WT5”BZ]The effective rates were 88.6% in levofloxacin group and 85.2% in cefaclor group, P >0.90 .The bacterial clearance rates were 85.7% in levofloxacin group and 86.7% in cefaclor group, P >0.90.The drug sensitivity rates of the relevant bacilli were 83.7% in levofloxacin group and 88.4% in cefaclor group.Serious side effects were not observed during the treatment course.[WT5”HZ]Conclusion[WT5”BZ] Levofloxacin is an effective antibiotic in the treatment of severe lower respiratory tract infection.