摘要
目的评价应用尼可地尔治疗冠状动脉慢血流现象(CSFP)的疗效及安全性。方法选择CSFP患者60例,按照随机、单盲和安慰剂对照的方法分为治疗组30例与对照组30例;观察治疗前、后两组临床症状的改善、胸痛发作频率与持续时间变化、6min步行实验的改变和校正的血流分级(TIMI)血流计数及下降程度的变化,以及治疗前、后血常规及肝肾功能指标变化。结果尼可地尔治疗组改善临床症状有效率优于对照组(P<0.01);尼可地尔治疗后,胸痛发作频率和持续时间较前减少(P<0.01,P<0.05),6min步行实验距离较前显著增加(P<0.01),校正的TIMI血流计数较前显著降低(P<0.01),且均优于对照组(P<0.01);患者血常规及肝肾功能检查治疗前、后均在正常范围(P>0.05)。结论尼可地尔治疗CSFP有较好的疗效且应用安全。
Objective To evaluate the effect and safety of nicorandil on Coronary Slow Flow Phenomenon（CSFP）.Methods The CSFP patients（n=60） were randomly divided into the control group treated with placebo and the treatment group treated with nicorandil.The changes of the clinical symptoms,the frequency and duration of pectoralgia,the six-minute walk test,and TIMI frame counts were observed before and after treatment.Results The treatment group had a better therapeutic effect than the control group（P0.05）.There were significant differences in the frequency and duration of pectoralgia,the six-minute walk test,and TIMI frame counts in treatment group before and after treatment,which were superior to those of control group（P0.05,P0.01）.The blood routine examinations and hepatorenal function were within the normal range before and after treatment.Conclusion Nicorandil has better therapeutic effect and safety on CSFP.
出处
《重庆医学》
CAS
CSCD
北大核心
2013年第24期2869-2870,2872,共3页
Chongqing medicine
