新型N-取代四氢噻吩并[3,2-c]吡啶类衍生物的合成及其抗血小板聚集活性

Synthesis and Anti-platelet Aggregation Activities of Novel N-substituted-tetrahydrothienopyridine Derivatives

以4,5,6,7-四氢噻吩并[3,2-c]吡啶为起始原料,设计并合成了一系列新型的含哌嗪结构的噻吩并吡啶类化合物(3a～3p),其结构经1H NMR,13C NMR,IR和ESI-HR-MS表征。大鼠体内抗血小板聚集活性研究表明,3a～3p均具有一定的抗血小板聚集作用,其中3a,3c,3i和3j的抑制率分别为66.8%,69.5%,70.4%和65.2%。

A series of novel piperazine-bearing thienopyridine derivatives（3a～3p） were designed and synthesized from 4,5,6,7-tetrahydrothienopyridine.The structures were characterized by 1H NMR,13C NMR,IR and ESI-HR-MS.In vivo anti-platelet aggregation tests in rats showed that 3a～3p exhibited certain anti-platelet aggregation activities.The inhibitions of 3a,3c,3i and 3j were 66.8%,69.5%,70.4% and 65.2%,respectively.