氟哌噻吨美利曲辛联合胃黏膜保护剂治疗慢性胃炎症状的疗效观察

Curative effects of flupentixol and melitracen tablets combined with protecting medicament of gastric mucosa on the treatment of chronic gastritis

目的观察氟哌噻吨美利曲辛干预焦虑、抑郁情绪治疗慢性胃炎患者的疗效。方法选择2010年7月—2011年8月门诊的128例慢性胃炎患者,随机分两组。对照组单用铝碳酸镁咀嚼片(达喜)1.0 g每日3次。治疗组给予氟哌噻吨美利曲辛每日晨服1片(含氟哌噻吨0.5 mg和美利曲辛10 mg)。同时服用铝碳酸镁咀嚼片(达喜)1.0 g每日3次。疗程为4周。结果经过4周治疗,联用氟哌噻吨美利曲辛治疗组临床症状改善明显,总有效率达到93.75%。单用胃黏膜保护剂对照组总有效率为82.81%。两组比较,差异有统计学意义(P<0.05)。结论氟哌噻吨美利曲辛通过改善焦虑情绪,合用铝碳酸镁咀嚼片治疗慢性胃炎,安全并显著提高疗效。

Objective To discuss intervention efficacy of flupentixol and melitracen tablets on anxious and depressed mood combined with protecting medicament of gastric mucosa in the treatment of chronic gastritis.Methods 128 cases with chronic gastritis were divided randomly into observation group and control group during July 2010 to August 2011,64 cases for each group.The control group was treated with the hydrotalcite chewable tablets 1.0 g,3 times a day.The observation group was on the basis of the treatment of the control group and added the antidepressant flupentixol and melitracen tablets 10.5 mg for each time,once foreach morning.The two groups were treated for 4 weeks.Results The total effective rate of the observation group was 93.75%,and the total effective rate of the control group was 82.81%.There was significant difference between the groups（P 0.05）.Conclusion The flupentixol and melitracen tablets which interfere in anxious and depressed mood can enhance the therapeutic effect remarkably,combined with the hydrotalcite chewable tablets is an effective and safe choice in treating chronic gastritis.