低剂量^(18)F-氟代脱氧葡萄糖PET/CT在体检中发现恶性肿瘤的意义

Significance of low-dose fluorodeoxyglucose PET/CT for screening of malignant tumors

目的评价低剂量18F-氟代脱氧葡萄糖(18F-FDG)PET/CT在体检中发现恶性肿瘤的意义。方法回顾分析2010年9月至2012年10月469例18F-FDGPET/CT健康体检者的资料,并对照随访结果。结果 18F-FDGPET/CT显像共发现恶性肿瘤13例,其中肺癌8例,甲状腺癌、贲门癌、卵巢癌、升结肠癌、肾细胞癌各1例。2例支气管肺泡癌、1例神经内分泌癌及1例肾细胞癌为假阴性,其余18F-FDG代谢均增高。结论低剂量18F-FDGPET/CT在体检中进行肿瘤筛查是安全的,具有重要意义。

Objective To assess the significance of low-dose fluorodeoxyglucose （^18F-FDG） PET/CT for screening of malignant tumors during physical examination. Methods We reviewed the clinical profiles of 469 individuals who received health cheek-up with ISF-FDG PET/CT. This entailed comparison with the findings during follow-up visits between September 2010 and October 2012. Results Thirteen patients with malignant tumors were identified by ^18F- FDG PET/CT, of whom 8 had pulmonary carcinoma, and a single case with thyroid cancer, cardiac carcinoma, ovarian cancer, ascending colon cancer and renal cancer, respectively. Except for 2 cases with bronchoalveolar carcinoma, 1 with neuroendocrine carcinoma and 1 with renal carcinoma judged to be false negative, all miscellaneous cases yielded an increased metabolism of ^18F-FDG. Conclusion Low-dose PET/CT is safe and significant for screening of malignancy in physical examination.