不同孕期妇女血清25-羟基维生素D水平的比较研究

A Comparative Study on Serum 25-hydroxy-vitamin D Levels of Pregnant Women in Different Periods

目的了解不同孕期妇女血清25-羟基维生素D[25(OH)D]水平分布及营养状况。方法选取2012年8—12月在杭州市余杭区妇幼保健院产科门诊及产前病区就诊的健康孕妇1899人,年龄为16～45岁,平均年龄(26±4)岁。按不同孕龄分成中孕期和晚孕期两组,其中,中孕期493人,晚孕期1406人。分别检测其血清25(OH)D水平,并比较两组结果的差异情况。结果中孕期妇女血清25(OH)D中位数为15.9(8.1～32.0)ng/mL,晚孕期妇女血清25(OH)D水平为20.0(10.0～37.9)ng/mL,两组孕妇血清25(OH)D水平比较,差异有统计学意义(P<0.01)。两组孕妇血清25(OH)D营养缺乏状况经两组独立样本的秩和检验,差异有统计学意义(P<0.01),表明不同孕期25(OH)D的营养状况有差异。结论孕妇普遍存在25(OH)D缺乏,在判断孕妇是否存在维生素D缺乏时,应在不同孕期采用不同的参考区间来判断。

Objective To investigate nutrition status and distribution of serum 25 - hydroxy vitamin D levels in pregnant women in Yuhang district. Methods 1899 healthy pregnant women who were diagnosed in maternal and child hospital of Yuhang from August to December in 2012 were recruited as subjects. All subjects were divided into second trimester group （493 cases） and third trimester group （406 cases） to detect serum 25 - hydroxy vitamin D levels. The differences of 25 - hydroxy vitamin D levels were compared between the two groups. Results The median of serum 25 - hydroxy vitamin D was 15.9 （ 8.1 - 32.0） ng/mL in second trimester group and was 20.0 （10.0- 37.9 ） ng/mL in third trimester group, and a significant difference was found between the two groups （Z = 11. 278, P 〈 0.01 ）. The differences of nutrition status between the two groups also indicated a statistical significance （ Z = 10. 262, P 〈 0. 01 ） after rank sum test. Conclusion Pregnant women widely have deficiency of 25 - hydroxy vitamin D and the pregnant women have a different value of 25 - hydroxy vitamin D in different pregnant periods.