输注静脉营养液滴系数的影响因素分析

Influencing Factors of Drop Coefficient of Total Nutrient Admixture Infusion

目的探讨输注静脉全营养混合液(total nutrient admixture,TNA)滴系数的主要影响因素,为临床计划输注TNA提供理论依据。方法模拟输液方法,测定2种不同配方的TNA在3种不同输注管道及2种不同滴注流量下5 mL的滴数各50次,计算出滴系数并比较其差异;测定2种不同配方TNA的表面张力、黏度及密度各20次,比较其差异。结果 2种不同配方TNA在同一滴注流量下同一输注管道中滴系数比较差异有统计学意义(P<0.01),不同滴注流量下同一种配方TNA在同一种输注管道滴系数的比较差异有统计学意义(P<0.01),不同输注管道中同一种配方TNA在同一滴注流量下滴系数的比较差异有统计学意义(P<0.05);2种不同配方TNA的表面张力、黏度及密度差异有统计学意义(P<0.01)。结论临床计划输注TNA时不能按管道包装上标注的滴系数来计算,在相同条件下输注与本研究相同配方的TNA滴系数可按本研究结果计算;输注不同配方TNA时,可利用本研究结果的规律来推测滴系数的值,精确的方法是在输前实测滴系数的值。

Objective To find out drop coefficient（drops in per mL） of total nutrient admixture（TNA） fluids infusion and its main influencing factors and to provide theoretical basis for planned TNA infusion in the clinical.Methods The drop number in 5 mL TNA with two different formulas in three different infusion tubes and with two different flow rate was measured for 50 times to calculate the average number of drop each milliliter.The influencing factors of drop coefficient were analyzed by measuring the viscosity,density and surface tension of two different formulas of TNA for 20 times.Results It was proved that the difference of drop coefficient between two TNAs with same flow rate and same infusion tube was statistical significant（P0.01）,and the difference of same TNA but with different flow rates（P0.01） and in different infusion tubes（P0.05） was statistical significant as well.The difference of the density,the surface tension and viscosity of TNA of different formulas was statistical significantly（P〈0.01）.Conclusion It suggests that we can＇ t calculate with the drop coefficient on the pipes marked on the package as planning TNA infusion in the clinical,while we can calculate with the results of drop coefficient on the condition of the same infusion and formula of TNA.We can speculate the value of drop coefficient through the law in this study in different formulations of TNA infusion.And we should reexamine the drop coefficient before TNA being used.