期刊文献+

幽门螺杆菌感染者胃液及血液表皮生长因子和前列腺素E_2含量研究 被引量:1

原文传递
导出
摘要 目的探讨胃液及血液表皮生长因子(epidemal growth factor,EGF)和前列腺素E2(prostaglandin E2,PGE2)含量在幽门螺杆菌(helicobacter pylori,HP)感染者中的意义。方法选取2007年1月—2010年6月门诊及住院患者76例,40例为HP感染者为HP阳性组,36例为非HP感染者为HP阴性组。EGF和PGE2试剂盒采用美国RD公司生产的ELISA试剂盒。计量资料采用t检验,P<0.05为差异有统计学意义。结果 HP阳性组血液、胃液EGF含量及血液PGE2含量[(2 946.61±113.52)、(429.00±89.14)、(221.04±9.35)ng/L]均明显高于HP阴性组,比较差异均有统计学意义(均P<0.05)。结论 HP感染者血液EGF和PGE2升高,胃液EGF升高,PGE2无差异,它们可能参与了HP相关性胃病形成的过程。
出处 《社区医学杂志》 2013年第14期15-16,共2页 Journal Of Community Medicine
  • 相关文献

参考文献8

  • 1Prlns C,Sehwendy S, Vohmd P. Hpylorl and gastric cancer: shifting the global burden[ J]. Word J Gestrcenterol,2006,12(34 ) :5458 - 5464.
  • 2Shajan P, Chrlstoph B. Helicobacter pylorl and gastric cancer:the causal relationship [J]. Digestion ,2077,75( 1 ) :25 -35.
  • 3Li WQ, Zh L, Ma JL, eta]. Association between genetic Pdymor- phisms of DNA baes excision repair genes and evolution of precan- cemns gastric lesions in a Chinese population[ J]. Carcino -gene- sis,2009,30(3) :500 -505.
  • 4Wallace JL, Ma L. Inflammatory mediators in gastrointestinal de- fense and injury[J]. Exp Biol Med (Maywood) ,2001,226:1003 - 1015.
  • 5Hoshino T, Tsutsumi S, Tomisato W, et al. Prostaglandin E2 pro- tecta gastric mucosal cells from apoptmis via EP2 and EP4 receptor aetlvatlonE J]. J Biol Chem ,2003,278 : 12752 - 12758 .
  • 6薛会光,易粹琼.胃黏膜对阿司匹林适应性的实验研究[J].中华消化杂志,2000,20(3):185-187. 被引量:8
  • 7TAKEUCHIK, OKABE So Mechanism of 8asic alkaline response in thestomach afteImnage: rolesofnitric oxide and prostaglandins[ J ]. DigDisSci, 1995,40:865.
  • 8刘冬梅.胃康舒对实验性慢性胃炎脾胃湿热证大鼠胃黏膜前列腺素E_2含量的影响[J].山西中医,2009,25(2):42-43. 被引量:6

二级参考文献12

  • 1潘文胜,赵文海,裴德恺,高静涛,李连宏.慢性胃炎实验模型的建立(组织病理学的动态观察)[J].大连医学院学报,1990,12(1):8-13. 被引量:35
  • 2Chiou SK, Tanigawa T, Akahoshi T, et al. Survivin: a noveltarget for indomethacin - induced gastric injury [ J ]. Gastroenterology, 2005(128) :63 -73.
  • 3RobertA,NezamisJE,LancasterC ,etal.Mildirritantspreventgastricnecrosisthrough"adaptivecytoprotection"mediatedbyprostaglandins[].American Journal of Physiology.1983
  • 4Konturek SJ,Brzozowski T,Stachura T,et al.Role of gastric blood flow, neutrophil infiltration, and mucosal cell proliferation in gastric adaptation to aspirin in the rat[].Gut.1994
  • 5Brzozowski T,Konturek PC,Konturek SJ,et al.Gastric adaptation to injury by repeated doses of aspirin strenghthens mucosal defence against subsequent exposure to various strong irritants in rats[].Gut.1995
  • 6Konturek SJ,Brzozowski T,Piastucki J,et al.Role of locally generated prostaglandins in adaptive gastric cytoprotection[].Digestive Diseases and Sciences.1982
  • 7Konturek JW,Dembinski A,Stoll R,et al.Mucosal adaptation to aspirin induced gastric damage in humans.Studies on blood flow,gastric mucosal growth, and neutrophil activation[].Gut.1994
  • 8Levi S,Goodland RA,Lee CY,et al.Inhibitory effect of nonsteroidal anti-inflammatory drugs on mucosal cell proliferation associated with gastric ulcer healing[].The Lancet.1990
  • 9Wallace JL.Non-steroidal anti-inflammatory drug gastropathy and cytoprotection: pathogenesis and mechanisms reexamined[].Scandinavian Journal of Gastroenterology.1992
  • 10杨春波,柯晓,李秀娟,傅肖岩,祁建生,杨永昇.脾胃湿热证的临床研究[J].福建中医学院学报,1999,9(4):1-6. 被引量:61

共引文献12

同被引文献25

引证文献1

二级引证文献25

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部