液相色谱-质谱联用仪的最佳校准条件的选择

Selection of Optimum Calibration Conditions in Calibrating Liquid Chromatograph-mass Spectrometer

液相色谱-质谱联用仪是将液相色谱仪与质谱仪通过一定的接口耦合到一起的分析仪器。本文从色质谱联用仪的工作原理及结构入手,针对仪器校准时的参数设置,通过分析色谱条件、仪器调谐、质谱条件等因素,介绍了色质联用仪最佳校准条件的选择技巧,有力保证了对液质联用仪进行准确的计量校准,为计量检定机构开展校准工作提供了参考。

Liquid chromatograph and mass spectrometer was coupled together to the analytical instrument by a certain interface. Based on the working principle and structure of Liquid chromatograph-mass spectrometer, for setting the calibration parameter of the instrument, the technique of selecting optimum calibration conditions in calibrating Liquid chromatograph-mass spectrometer was studied by the analysis of the chromatographic conditions, instrument tuning and mass spectrometry conditions. So it could ensure to calibrate Liquid chromatograph-mass spectrometer accurately and provide some guidance on the calibration for Metrological institutions.